Multi-view convolutional neural networks for automated ocular structure and tumor segmentation in retinoblastoma.

Details

Serval ID
serval:BIB_61A3D7FC211B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multi-view convolutional neural networks for automated ocular structure and tumor segmentation in retinoblastoma.
Journal
Scientific reports
Author(s)
Strijbis VIJ, de Bloeme C.M., Jansen R.W., Kebiri H., Nguyen H.G., de Jong M.C., Moll A.C., Bach-Cuadra M., de Graaf P., Steenwijk M.D.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
16/07/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
14590
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In retinoblastoma, accurate segmentation of ocular structure and tumor tissue is important when working towards personalized treatment. This retrospective study serves to evaluate the performance of multi-view convolutional neural networks (MV-CNNs) for automated eye and tumor segmentation on MRI in retinoblastoma patients. Forty retinoblastoma and 20 healthy-eyes from 30 patients were included in a train/test (N = 29 retinoblastoma-, 17 healthy-eyes) and independent validation (N = 11 retinoblastoma-, 3 healthy-eyes) set. Imaging was done using 3.0 T Fast Imaging Employing Steady-state Acquisition (FIESTA), T2-weighted and contrast-enhanced T1-weighted sequences. Sclera, vitreous humour, lens, retinal detachment and tumor were manually delineated on FIESTA images to serve as a reference standard. Volumetric and spatial performance were assessed by calculating intra-class correlation (ICC) and dice similarity coefficient (DSC). Additionally, the effects of multi-scale, sequences and data augmentation were explored. Optimal performance was obtained by using a three-level pyramid MV-CNN with FIESTA, T2 and T1c sequences and data augmentation. Eye and tumor volumetric ICC were 0.997 and 0.996, respectively. Median [Interquartile range] DSC for eye, sclera, vitreous, lens, retinal detachment and tumor were 0.965 [0.950-0.975], 0.847 [0.782-0.893], 0.975 [0.930-0.986], 0.909 [0.847-0.951], 0.828 [0.458-0.962] and 0.914 [0.852-0.958], respectively. MV-CNN can be used to obtain accurate ocular structure and tumor segmentations in retinoblastoma.
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2021 9:07
Last modification date
07/08/2021 6:37
Usage data