Detailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_617DFD73A379
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Detailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series
Journal
Annals of Oncology
Author(s)
Bulliard Jean-Luc, De Weck Daniel, Fisch Thomas, Bordoni Andrea, Levi Fabio
ISSN
0923-7534
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
18
Number
4
Pages
789-794
Abstract
BACKGROUND: The relation between detailed cutaneous distribution of melanoma and indicators of sun exposure patterns has scantily been explored in moderately sun-sensitive populations. PATIENTS AND METHODS: The precise site of 1658 primary malignant melanoma, registered from 1995 to 2002, in Switzerland were retrieved and clinically validated. Relative melanoma density (RMD) was computed by the ratio of observed to expected number of melanoma allowing for body site surface areas, and further adjusted for site-specific melanocyte density. RESULTS: Sites of highest risks were the face, shoulder and upper arm for both sexes, the back for men, and leg for women. Major features of this series were: (i) an unexpectedly high RMD for the face in women (5.6 versus 3.7 in men), (ii) the absence of a male predominance for melanoma on the ears and (iii) for the upper limbs, a steady gradient of increasing melanoma density with increasing proximity to the trunk, regardless of sex. Age and sex patterns of RMD parallelled general indicators of sun exposure and behaviour, except for the hand (RMD = 0.2). CONCLUSION: RMD increased with (cumulative) site sun exposure, but a few notable exceptions support the impact of intermittent exposure in melanoma risk.
Keywords
Melanoma , Neoplasms, Radiation-Induced , Skin Neoplasms , Sunlight
Pubmed
Web of science
Open Access
Yes
Create date
05/02/2008 11:15
Last modification date
25/09/2019 7:09
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