A systematic review and meta-analysis of perineural dexamethasone for peripheral nerve blocks.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_61511FFCFE82
Type
Article: article from journal or magazin.
Collection
Publications
Title
A systematic review and meta-analysis of perineural dexamethasone for peripheral nerve blocks.
Journal
Anaesthesia
Author(s)
Albrecht E., Kern C., Kirkham K.R.
ISSN
1365-2044 (Electronic)
ISSN-L
0003-2409
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
70
Number
1
Pages
71-83
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
We systematically reviewed the safety and efficacy of perineural dexamethasone as an adjunct for peripheral nerve blockade in 29 controlled trials of 1695 participants. We grouped trials by the duration of local anaesthetic action (short- or medium- vs long-term). Dexamethasone increased the mean (95% CI) duration of analgesia by 233 (172-295) min when injected with short- or medium-term action local anaesthetics and by 488 (419-557) min when injected with long-term action local anaesthetics, p < 0.00001 for both. However, these results should be interpreted with caution due to the extreme heterogeneity of results, with I2 exceeding 90% for both analyses. Meta-regression did not show an interaction between dose of perineural dexamethasone (4-10 mg) and duration of analgesia (r2 = 0.02, p = 0.54). There were no differences between 4 and 8 mg dexamethasone on subgroup analysis.
Keywords
Adjuvants, Anesthesia/administration & dosage, Analgesia/methods, Anesthetics, Local/administration & dosage, Dexamethasone/administration & dosage, Dose-Response Relationship, Drug, Humans, Nerve Block/methods, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2015 14:59
Last modification date
20/08/2019 15:18
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