Networks of blood proteins in the neuroimmunology of schizophrenia.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_61413D23E213
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Networks of blood proteins in the neuroimmunology of schizophrenia.
Journal
Translational psychiatry
Author(s)
Jeffries C.D., Perkins D.O., Fournier M., Do K.Q., Cuenod M., Khadimallah I., Domenici E., Addington J., Bearden C.E., Cadenhead K.S., Cannon T.D., Cornblatt B.A., Mathalon D.H., McGlashan T.H., Seidman L.J., Tsuang M., Walker E.F., Woods S.W.
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Publication state
Published
Issued date
06/06/2018
Peer-reviewed
Oui
Volume
8
Number
1
Pages
112
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: epublish
Abstract
Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks that could be prognostic. We analyzed baseline blood plasma samples with a Luminex platform from 72 subjects meeting criteria for a psychosis clinical high-risk syndrome; 32 subjects converted to a diagnosis of psychotic disorder within two years while 40 other subjects did not. Another comparison group included 35 unaffected subjects. Assays of 141 analytes passed early quality control. We then used an unweighted co-expression network analysis to identify highly correlated modules in each group. Overall, there was a striking loss of network complexity going from unaffected subjects to nonconverters and thence to converters (applying standard, graph-theoretic metrics). Graph differences were largely driven by proteins regulating tissue remodeling (e.g. blood-brain barrier). In more detail, certain sets of antithetical proteins were highly correlated in unaffected subjects (e.g. SERPINE1 vs MMP9), as expected in homeostasis. However, for particular protein pairs this trend was reversed in converters (e.g. SERPINE1 vs TIMP1, being synthetical inhibitors of remodeling of extracellular matrix and vasculature). Thus, some correlation signals strongly predict impending conversion to a psychotic disorder and directly suggest pharmaceutical targets.
Keywords
Adolescent, Adult, Biomarkers/blood, Blood Proteins/analysis, Female, Humans, Longitudinal Studies, Male, Matrix Metalloproteinase 9/blood, Neuroimmunomodulation, Plasminogen Activator Inhibitor 1/blood, Schizophrenia/blood, Schizophrenia/diagnosis, Schizophrenia/immunology, Tissue Inhibitor of Metalloproteinase-1/blood, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
11/06/2018 15:42
Last modification date
20/08/2019 15:18
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