Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cells.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_612B428BDFF5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cells.
Journal
European journal of pharmaceutics and biopharmaceutics
Author(s)
Vorobiev V., Adriouach S., Crowe L.A., Lenglet S., Thomas A., Chauvin A.S., Allémann E.
ISSN
1873-3441 (Electronic)
ISSN-L
0939-6411
Publication state
Published
Issued date
01/2021
Peer-reviewed
Oui
Volume
158
Pages
347-358
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Molecular medical imaging is intended to increase the accuracy of diagnosis, particularly in cardiovascular and cancer-related diseases, where early detection could significantly increase the treatment success rate. In this study, we present mixed micelles formed from four building blocks as a magnetic resonance imaging targeted contrast agent for the detection of atheroma and cancer cells. The building blocks are a gadolinium-loaded DOTA ring responsible for contrast enhancement, a fibrin-specific CREKA pentapeptide responsible for targeting, a fluorescent dye and DSPE-PEG <sub>2000</sub> . The micelles were fully characterized in terms of their size, zeta potential, stability, relaxivity and toxicity. Target binding assays performed on fibrin clots were quantified by fluorescence and image signal intensities and proved the binding power. An additional internalization assay showed that the micelles were also designed to specifically enter into cancer cells. Overall, these multimodal mixed micelles represent a potential formulation for MRI molecular imaging of atheroma and cancer cells.
Keywords
Fibrin targeting, MRI contrast agent, Micelles, Molecular imaging, Multimodal
Pubmed
Web of science
Open Access
Yes
Create date
04/12/2020 14:49
Last modification date
13/03/2021 7:22
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