Relationship between humoral response to Plasmodium falciparum merozoite surface antigen-2 and malaria morbidity in a highly endemic area of Papua New Guinea

Details

Serval ID
serval:BIB_612779DAB12C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relationship between humoral response to Plasmodium falciparum merozoite surface antigen-2 and malaria morbidity in a highly endemic area of Papua New Guinea
Journal
American Journal of Tropical Medicine and Hygiène
Author(s)
al-Yaman  F., Genton  B., Anders  R. F., Falk  M., Triglia  T., Lewis  D., Hii  J., Beck  H. P., Alpers  M. P.
ISSN
0002-9637 (Print)
Publication state
Published
Issued date
11/1994
Volume
51
Number
5
Pages
593-602
Notes
Journal Article
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Nov
Abstract
The prevalence and concentration of antibodies to merozoite surface antigen-2 (MSA-2) were measured in blood samples collected during a cross-sectional survey. Antibodies were measured by enzyme-linked immunosorbent assay using two recombinant proteins that closely approximated the full-length mature MSA-2 polypeptides expressed by the Plasmodium falciparum isolate FC27 and the cloned line 3D7 and that were representative of the dimorphic forms of MSA-2. Antibodies were also measured to a form of the 3D7 MSA-2 lacking the central repetitive sequences (d3D7). High antibody prevalence was observed to all three antigens: the overall prevalence of IgG to FC27, 3D7, and d3D7 was 91%, 90%, and 90%, respectively. The majority of individuals > or = 5 years of age had antibodies to both forms of MSA-2. The geometric mean antibody units increased with age with a plateau being reached by 15-20 years of age. There was a significant positive association of antibody prevalence with both the presence of the parasite and an enlarged spleen in children. This study provides the first evidence that antibodies against nonrepeat regions of MSA-2 are associated with fewer fever episodes and less anemia, both known to be indicators of malaria morbidity.
Keywords
Adolescent Adult Age Factors Animals Antibodies, Protozoan/*blood *Antigens, Protozoan Antigens, Surface/immunology Chi-Square Distribution Child Child, Preschool Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Fever Humans Infant Infant, Newborn Malaria, Falciparum/*epidemiology/immunology Morbidity Papua New Guinea/epidemiology Parasitemia/epidemiology/parasitology Plasmodium falciparum/*immunology Prevalence Protozoan Proteins/*immunology Recombinant Proteins/immunology Spleen/pathology
Pubmed
Web of science
Create date
28/01/2008 11:48
Last modification date
20/08/2019 14:18
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