Jambes lourdes, insuffisance veineuse des membres inférieurs et hormonothérapie substitutive [Heavy legs, venous insufficiency of the legs and hormone substitution therapy]

Details

Serval ID
serval:BIB_6111BE66C0E7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Jambes lourdes, insuffisance veineuse des membres inférieurs et hormonothérapie substitutive [Heavy legs, venous insufficiency of the legs and hormone substitution therapy]
Journal
Praxis
Author(s)
Haesler E., Hayoz D.
ISSN
1661-8157
Publication state
Published
Issued date
2000
Volume
89
Number
25-26
Pages
1098-104
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review - Publication Status: ppublish
Abstract
The effects of estrogens and gestagens on veins and circulation have been studied since prescription of these hormones as oral contraception and description of related thromboembolic events. The identification of different receptors and the description of these receptors in venous walls have helped to understand some hormonal effects. However, the actual knowledge remains insufficient to explain the complexity of the actions of hormones on venous function. The distribution, the density and the receptor types vary with age, gender, hormonal status and vascular bed. Gestagens mainly reduce the tone of venous walls, whereas estrogens have various effects. Between 25% and 50% of European adults and even 80% or more in some risk groups complain about heavy legs, with or without chronic venous insufficiency. The number of women to whom hormonal substitution is or could be prescribed increases along with aging of populations and the better understanding of potential benefits. The need for a better understanding of vascular effects of sexual hormones is growing, since the incidence of chronic venous insufficiency of the legs increases with age. The life prognosis will not be affected by a deterioration of a chronic venous insufficiency. In contrast, the quality of life, morbidity and the cost of treatment will be expected to change. In addition, thromboembolic events have to be considered, as has been shown in recent studies. These findings outline the need for further studies on the relation between hormones and venous function and for some caution when prescribing hormonal substitution.
Keywords
Adult, Age Factors, Aged, Contraceptives, Oral, Hormonal, Estrogen Replacement Therapy, Female, Humans, Middle Aged, Pulmonary Embolism, Risk Factors, Venous Insufficiency, Venous Thrombosis
Pubmed
Create date
29/01/2008 8:56
Last modification date
20/08/2019 14:18
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