Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_610E6C9C19DA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma.
Journal
Human pathology
Author(s)
Sciarra A., Park Y.N., Sempoux C.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Publication state
Published
Issued date
02/2020
Peer-reviewed
Oui
Volume
96
Pages
48-55
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma showing variable degrees of differentiation toward hepatocellular and cholangiocellular carcinoma. Its great heterogeneity in term of morphology, immunophenotype, molecular, radiological and clinical features represents a challenge still to overcome. The multidisciplinary 2018 International Consensus on the nomenclature of cHCC-CCA allowed to define key issues of this entity. Here we review the historical controversies of cHCC-CCA, resume the key elements of the 2018 consensus, now incorporated in the 2019 WHO classification, and propose a short survival guide to help surgical pathologists facing cHCC-CCA in their routine workup.
Keywords
Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Biopsy, Carcinoma, Hepatocellular/chemistry, Carcinoma, Hepatocellular/genetics, Carcinoma, Hepatocellular/pathology, Carcinoma, Hepatocellular/therapy, Cholangiocarcinoma/chemistry, Cholangiocarcinoma/genetics, Cholangiocarcinoma/pathology, Cholangiocarcinoma/therapy, Humans, Immunohistochemistry, Liver Neoplasms/chemistry, Liver Neoplasms/genetics, Liver Neoplasms/pathology, Liver Neoplasms/therapy, Molecular Diagnostic Techniques, Neoplasms, Complex and Mixed/chemistry, Neoplasms, Complex and Mixed/genetics, Neoplasms, Complex and Mixed/pathology, Neoplasms, Complex and Mixed/therapy, Predictive Value of Tests, Prognosis, Cholangiocarcinoma, Cholangiolocarcinoma, Combined hepatocellular-cholangiocarcinoma, Hepatocellular carcinoma, Primary liver carcinoma
Pubmed
Web of science
Create date
15/01/2020 15:45
Last modification date
25/07/2020 5:19
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