Diagnostik und Prävention des Harnsäuresteins

Details

Serval ID
serval:BIB_610C5E749512
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Diagnostik und Prävention des Harnsäuresteins
Journal
Therapeutische Umschau
Author(s)
Ferrari P., Bonny O.
ISSN
0040-5930 (Print)
ISSN-L
0040-5930
Publication state
Published
Issued date
2004
Volume
61
Number
9
Pages
571-574
Language
german
Notes
[Diagnosis and prevention of uric acid stones].
Abstract
Uric acid stones occur in 10% of all kidney stones and are the second most-common cause of urinary stones after calcium oxalate and calcium phosphate calculi. The most important risk factor for uric acid crystallization and stone formation is a low urine pH (below 5.5) rather than an increased urinary uric acid excretion. Main causes of low urine pH are tubular disorders (including gout), chronic diarrhea or severe dehydration. Uric acid stone disease can be prevented and these are one of the few urinary tract stones that can be dissolved successfully. The treatment of uric acid stones consists not only of hydration (urine volume above 2000 ml daily), but mainly of urine alkalinization to pH values between 6.2 and 6.8. Urinary alkalization with potassium citrate or sodium bicarbonate is a highly effective treatment, resulting in dissolution of existing stones. Urinary uric acid excretion can be reduced by a low-purine diet. Potassium citrate is the treatment of choice for the prevention of recurrence of uric acid calculi. Allopurinol reduces the frequency of stone formation in hyperuricosuric patients with recurrent uric acid stones and/or gout.
Keywords
Adult, Allopurinol/therapeutic use, Female, Fluid Therapy, Humans, Hydrogen-Ion Concentration, Hyperuricemia/diagnosis, Hyperuricemia/therapy, Kidney Calculi/diagnosis, Kidney Calculi/prevention & control, Kidney Function Tests, Male, Risk Factors, Tomography, X-Ray Computed, Uric Acid/urine, Uricosuric Agents/therapeutic use, Urodynamics/drug effects
Pubmed
Create date
01/02/2010 11:21
Last modification date
20/08/2019 14:18
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