Adipose tissue is a regulated source of interleukin-10

Details

Serval ID
serval:BIB_60FB64E5DD0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Adipose tissue is a regulated source of interleukin-10
Journal
Cytokine
Author(s)
Juge-Aubry  C. E., Somm  E., Pernin  A., Alizadeh  N., Giusti  V., Dayer  J. M., Meier  C. A.
ISSN
1043-4666 (Print)
Publication state
Published
Issued date
03/2005
Volume
29
Number
6
Pages
270-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 21
Abstract
White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).
Keywords
Adipose Tissue/*immunology/secretion Animals Gene Expression Regulation Humans Interleukin-10/*biosynthesis/genetics/secretion Mice Mice, Inbred C57BL Obesity/genetics/*immunology RNA, Messenger/biosynthesis
Pubmed
Web of science
Create date
25/01/2008 16:23
Last modification date
20/08/2019 14:18
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