Effect of hospital-acquired ventilator-associated pneumonia on mortality of severe community-acquired pneumonia

Details

Serval ID
serval:BIB_60EA33ACD6B5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of hospital-acquired ventilator-associated pneumonia on mortality of severe community-acquired pneumonia
Journal
J Crit Care
Author(s)
Leroy O., Guilley J., Georges H., Choisy P., Guery B., Alfandari S., Beaucaire G.
ISSN
0883-9441 (Print)
ISSN-L
0883-9441
Publication state
Published
Issued date
03/1999
Volume
14
Number
1
Pages
12-9
Language
english
Notes
Leroy, O
Guilley, J
Georges, H
Choisy, P
Guery, B
Alfandari, S
Beaucaire, G
eng
J Crit Care. 1999 Mar;14(1):12-9. doi: 10.1016/s0883-9441(99)90003-5.
Abstract
PURPOSE: The purpose of this article is to evaluate, using two pairwise case-control studies, attributable mortality linked to hospital-acquired ventilator-associated pneumonia (HA-VAP) complicating the intensive care unit (ICU) stay of patients exhibiting severe community-acquired pneumonia (CAP). MATERIALS AND METHODS: Over an 11-year period, 498 patients with severe CAP were collected. Among them, 43 exhibited HA-VAP. In a first case-control study, these patients were matched with control on the basis of six confounding variables known to be general ICU prognosis factors. In a second case-control study, six variables specifically linked to CAP prognosis were used for matching. RESULTS: In the two case-control studies, each case patient was matched with one control patient. In the first analysis, success of matching was achieved in 198 of 258 (77%) variables used for matching. In the second analysis, matching was successful for 242 of 258 (94%) confounding variables used. Eighteen patients died, compared with, respectively, 6 (P = .003) and 7 (P = .01) controls. Attributable mortality of HA-VAP was similar in the two pairwise analyses, respectively, 28% (risk ratio = 3.0; 95% confidence interval, 1.32 to 6.82) and 26% (risk ratio = 2.57; 95% confidence interval, 1.2 to 5.52). CONCLUSION: When confounding factors were controlled, HA-VAP appeared to increase mortality of severe CAP requiring ICU admission.
Keywords
Aged, Case-Control Studies, Community-Acquired Infections/*complications/mortality/therapy, Confounding Factors, Epidemiologic, *Critical Care, Cross Infection/*complications/etiology/mortality, Female, Glasgow Coma Scale, Humans, Male, Middle Aged, Pneumonia, Bacterial/complications/*mortality/therapy, Prognosis, Prospective Studies, Respiration, Artificial/*adverse effects, Respiratory Insufficiency/etiology/therapy, Retrospective Studies, Severity of Illness Index, Survival Analysis
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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