Degenerescence cerebelleuse paraneoplasique auto-immune. [Autoimmune paraneoplastic cerebellar degeneration]

Details

Serval ID
serval:BIB_60DE3CD34D67
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Degenerescence cerebelleuse paraneoplasique auto-immune. [Autoimmune paraneoplastic cerebellar degeneration]
Journal
Revue Neurologique
Author(s)
Lovblad  K. O., Henny  C., Boucraut  J., Graus  F., Delaloye  J. F., Bernard  D., Steck  A. J., Regli  F.
ISSN
0035-3787 (Print)
Publication state
Published
Issued date
1994
Volume
150
Number
1
Pages
46-9
Notes
Case Reports
English Abstract
Journal Article
Abstract
Paraneoplastic cerebellar degeneration is a well-defined clinical entity typically associated with ovarian or breast carcinoma. Serum or CSF of these patients has been shown to contain autoantibodies against the cytoplasm of Purkinje cells. These antibodies have been referred to as anti-Yo. We report the case of a 67-year old woman with ovarian adenocarcinoma presenting with subacute cerebellar dysfunction. Her serum was found to react with the cytoplasm of Purkinje cells and HeLa cells. On Western blot analysis a 60 to 70 kD reaction was obtained. This suggests the presence of a classical anti-Yo antibody.
Keywords
Adenocarcinoma/*complications Aged *Autoimmune Diseases Female Humans Immunohistochemistry Ovarian Neoplasms/*complications *Paraneoplastic Syndromes/immunology Purkinje Cells/immunology Spinocerebellar Degenerations/diagnosis/*etiology Tomography, X-Ray Computed Tumor Cells, Cultured
Pubmed
Web of science
Create date
25/01/2008 15:42
Last modification date
20/08/2019 14:18
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