Failure of dexamethasone to prevent polymorphonuclear leukocyte infiltration during experimental acute exudative pyelonephritis and to reduce subsequent chronic scarring

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Serval ID
serval:BIB_60C39F92626F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Failure of dexamethasone to prevent polymorphonuclear leukocyte infiltration during experimental acute exudative pyelonephritis and to reduce subsequent chronic scarring
Journal
Journal of Infectious Diseases
Author(s)
Meylan  P. R., Glauser  M. P.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
03/1988
Volume
157
Number
3
Pages
480-5
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
In experimental acute exudative pyelonephritis (AEP), a role for polymorphonuclear leukocyte (PMNL) infiltration in the pathogenesis of kidney scarring has been suggested indirectly. To directly quantitate PMNL infiltration during AEP, we developed an assay for measuring the content in the kidney of myeloperoxidase (MPO), an enzyme present in PMNLs and absent in kidney tissue. This assay was a specific and sensitive marker of the kidney PMNL content. We used this assay to measure in rats with AEP the effect of dexamethasone, administered in an attempt to mitigate the acute inflammatory response. Compared with saline, dexamethasone given during AEP strikingly reduced kidney swelling, measured by the kidney-weight increase, but failed to reduce PMNL infiltration, measured by the kidney MPO content. Despite reduced kidney swelling during AEP, dexamethasone treatment failed to prevent subsequent kidney scarring, an observation indicating that PMNLs play a role in the development of permanent kidney damage during AEP.
Keywords
Acute Disease Animals Dexamethasone/blood/*pharmacology Kidney/microbiology/pathology Neutrophils/enzymology/*physiology Organ Size Peroxidase/metabolism Pyelonephritis/microbiology/*pathology Rats
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:32
Last modification date
01/10/2019 7:18
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