Insights into the Role of PPARβ/δ in NAFLD.

Details

Ressource 1Download: ijms-19-01893.pdf (1829.74 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_607C77FFAC76
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Insights into the Role of PPARβ/δ in NAFLD.
Journal
International journal of molecular sciences
Author(s)
Chen J., Montagner A., Tan N.S., Wahli W.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
27/06/2018
Peer-reviewed
Oui
Volume
19
Number
7
Pages
1893
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries. Although usually associated with obesity, NAFLD is also diagnosed in individuals with low body mass index (BMI) values, especially in Asia. NAFLD can progress from steatosis to non-alcoholic steatohepatitis (NASH), which is characterized by liver damage and inflammation, leading to cirrhosis and hepatocellular carcinoma (HCC). NAFLD development can be induced by lipid metabolism alterations; imbalances of pro- and anti-inflammatory molecules; and changes in various other factors, such as gut nutrient-derived signals and adipokines. Obesity-related metabolic disorders may be improved by activation of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)β/δ, which is involved in metabolic processes and other functions. This review is focused on research findings related to PPARβ/δ-mediated regulation of hepatic lipid and glucose metabolism and NAFLD development. It also discusses the potential use of pharmacological PPARβ/δ activation for NAFLD treatment.
Keywords
Animals, Carcinoma, Hepatocellular/drug therapy, Carcinoma, Hepatocellular/metabolism, Humans, Liver Neoplasms/drug therapy, Liver Neoplasms/metabolism, Non-alcoholic Fatty Liver Disease/drug therapy, Non-alcoholic Fatty Liver Disease/metabolism, PPAR delta/metabolism, PPAR delta/therapeutic use, PPAR-beta/metabolism, PPAR-beta/therapeutic use, NAFLD, NASH, PPARβ/δ, lipid metabolism, liver, steatosis
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2018 7:34
Last modification date
20/08/2019 14:17
Usage data