Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus.

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Serval ID
serval:BIB_6073D1D704FA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus.
Journal
Frontiers in Neuroscience
Author(s)
Sultan S., Gebara E., Toni N.
ISSN
1662-453X; 1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
7
Number
131
Pages
131
Language
english
Notes
Sultan S et Gebara E. : co-first author
Abstract
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. Although inducible-reversible transgenic mouse models are increasingly being used to investigate adult neurogenesis, transgene control requires the administration of an activator, doxycycline (Dox), with unknown effects on adult neurogenesis. Here, we tested the effect of Dox administration on adult neurogenesis in vivo. We found that 4 weeks of Dox treatment at doses commonly used for gene expression control, resulted in increased neurogenesis. Furthermore, the dendrites of new neurons displayed increased spine density. Concomitantly, Iba1-expressing microglia was reduced by Dox treatment. These results indicate that Dox treatment may interfere with parameters of relevance for the use of inducible transgenic mice in studies of adult neurogenesis or brain inflammation.
Pubmed
Web of science
Open Access
Yes
Create date
07/08/2013 11:08
Last modification date
20/08/2019 14:17
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