Rapidly progressive familial parkinsonism with central hypoventilation, depression and weight loss (Perry syndrome)--a literature review.

Details

Serval ID
serval:BIB_604DD77DE68A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Rapidly progressive familial parkinsonism with central hypoventilation, depression and weight loss (Perry syndrome)--a literature review.
Journal
Parkinsonism and Related Disorders
Author(s)
Wider C., Wszolek Z.K.
ISSN
1353-8020[print], 1353-8020[linking]
Publication state
Published
Issued date
2008
Volume
14
Number
1
Pages
1-7
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Abstract
Autosomal dominant parkinsonism, hypoventilation, depression and weight loss (Perry syndrome) has been reported in only seven families worldwide. It is a rapidly progressive disease leading to death from respiratory insufficiency within a few years. Parkinsonism is usually mild, with bradykinesia, rigidity, rest and postural tremor, and axial signs. Response to levodopa is poor although transient response has been occasionally observed. The early signs include parkinsonism, depression and weight loss, whereas hypoventilation is a late feature. Neuropathology shows severe neuronal loss in the substantia nigra, less prominent neuronal loss in the locus coeruleus, and no or few Lewy bodies. In this review, we also propose diagnostic criteria for this condition.
Keywords
Depression/complications, Depression/diagnosis, Humans, Hypoventilation/complications, Hypoventilation/diagnosis, Parkinsonian Disorders/complications, Parkinsonian Disorders/diagnosis, Syndrome, Weight Loss
Pubmed
Create date
24/09/2010 18:11
Last modification date
20/08/2019 14:17
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