Myoepithelioma of the cerebellopontine angle: a previously not documented benign salivary gland-type neoplasm within the cranium.

Details

Serval ID
serval:BIB_603A3C1185BB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Myoepithelioma of the cerebellopontine angle: a previously not documented benign salivary gland-type neoplasm within the cranium.
Journal
Clinical neuropathology
Author(s)
Vajtai I., Hewer E., Neuenschwander M., Schäfer S.C., Kappeler A., Lukes A.
ISSN
0722-5091 (Print)
ISSN-L
0722-5091
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
32
Number
3
Pages
176-182
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
PDF: Article.
Abstract
Myoepithelioma is a dimorphic neoplasm with contractile-epithelial phenotype, originally interpreted as deriving from, but not actually restricted to the salivary glands. As a novel addition to the list of exquisitely rare intracranial salivary gland-type tumors and tumor-like lesions, we report on an example of myoepithelioma encountered in the left cerebellopontine angle of a 32-year-old male. Clinically presenting with ataxia and dizziness, this extraaxial mass of 4 × 3.5 × 3 cm was surgically resected, and the patient is alive 6 years postoperatively. Histologically, the tumor exhibited a continuum ranging from compact fascicles of spindle cells to epithelial nests and trabeculae partitioned by hyalinized septa, while lacking tubular differentiation. Regardless of architectural variations, there was robust immunoexpression of S100 protein, smooth muscle actin, GFAP, cytokeratin, and vimentin. Cytologic atypia tended to be modest throughout, and the MIB1 labeling index averaged less than 1%. Fluorescent in situ hybridization indicated no rearrangement of the EWSR1 locus. We interpret these results to suggest that myoepithelioma of the posterior fossa - along with related salivary epithelial tumors in this ostensibly incongruous locale - may possibly represent analogous neoplasms to their orthotopic counterparts, ones arising within aberrant salivary anlagen. The presence of the latter lends itself to being mechanistically accounted for by either postulating placodal remnants in the wake of branchial arch development, or linking them to exocrine glandular nests within endodermal cysts. Alternatively, myoepithelioma at this site could be regarded as a non tissue-specific lesion similar to its relatives ubiquitously occurring in the soft parts.
Keywords
Adult, Biomarkers, Tumor/analysis, Cerebellar Neoplasms/metabolism, Cerebellar Neoplasms/pathology, Cerebellar Neoplasms/surgery, Cerebellopontine Angle/metabolism, Cerebellopontine Angle/pathology, Cerebellopontine Angle/surgery, Humans, Immunohistochemistry, Male, Myoepithelioma/metabolism, Myoepithelioma/pathology, Myoepithelioma/surgery, Skull/pathology
Pubmed
Web of science
Create date
31/08/2020 13:02
Last modification date
10/11/2020 7:26
Usage data