Risk factors and determinants of carotid intima-media thickness in children: protocol for a systematic review and meta-analysis.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_6026FC2F9B07
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk factors and determinants of carotid intima-media thickness in children: protocol for a systematic review and meta-analysis.
Journal
BMJ open
Author(s)
Epure A.M., Leyvraz M., Mivelaz Y., Di Bernardo S., da Costa B.R., Chiolero A., Sekarski N.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
04/06/2018
Peer-reviewed
Oui
Volume
8
Number
6
Pages
e019644
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Carotid intima-media thickness (CIMT) is a surrogate marker of atherosclerosis that is measured in adults and children to better understand the natural history of cardiovascular disease (CVD). In adults, CIMT is predictive of myocardial infarction and stroke. In children and adolescents, CIMT is used to assess vascular changes in the presence of CVD risk factors (obesity, hypertension, smoking, etc) or clinical conditions associated with a high risk for premature CVD. However, there is no comprehensive overview, in a life-course epidemiology perspective, of the risk factors and determinants of CIMT in children. It is also important to evaluate between-study differences in CIMT measurement methods and take them into consideration when drawing conclusions. Our objective is to systematically review the evidence on the relationship between CIMT and prenatal and postnatal exposures or interventions in children, as well as documenting and discussing the CIMT measurement methods.
Systematic searches of the Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica (EMBASE)and Central Register of Controlled Trials (CENTRAL) databases will be conducted. The reference lists and other literatures sources will be browsed. Observational and experimental studies in children from birth up to 18 years will be included. Prenatal and postnatal exposures or interventions assessed in relationship with CIMT will be considered for inclusion. Examples might include gestational age, obesity, hypertension, tobacco exposure, specific at-risk conditions (chronic kidney disease, diabetes, etc) or statin treatment. The outcome will be CIMT assessed by ultrasonography. The setting, scanning and measurement methods for each included study will be described in detail. Results will be synthesised descriptively and, if appropriate, will be pooled across studies to perform meta-analyses. Separate meta-analyses for each exposure or intervention type will be conducted.
This systematic review will be published in a peer-reviewed journal. A report will be prepared for clinicians and other healthcare decision-makers.
CRD42017075169.
Keywords
Adolescent, Atherosclerosis/epidemiology, Atherosclerosis/etiology, Biomarkers, Carotid Intima-Media Thickness, Child, Humans, Meta-Analysis as Topic, Research Design, Risk Assessment, Risk Factors, Systematic Reviews as Topic, adolescent, atherosclerosis, cardiovascular disease, carotid intima-media thickness, child, ultrasonography
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2018 17:40
Last modification date
04/10/2019 11:08
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