Targeting Tanycytes: Balance between Efficiency and Specificity.

Details

Serval ID
serval:BIB_5FFBA62BEE85
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Targeting Tanycytes: Balance between Efficiency and Specificity.
Journal
Neuroendocrinology
Author(s)
Langlet F.
ISSN
1423-0194 (Electronic)
ISSN-L
0028-3835
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
110
Number
7-8
Pages
574-581
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Tanycytes are peculiar ependymoglial cells lining the bottom and the lateral wall of the third ventricle. For a decade, the utilization of molecular genetic approaches allowed us to make important discoveries about their diverse physiological functions. Here, I review the current methods used to target tanycytes, focusing on their specificity, their efficiency, their limitations, as well as their potential future improvements.
Keywords
Animals, Drug Delivery Systems/methods, Ependymoglial Cells/cytology, Ependymoglial Cells/metabolism, Ependymoglial Cells/physiology, Gene Expression Regulation, Gene Targeting/methods, Humans, Sensitivity and Specificity, Third Ventricle, Adeno-associated virus, Adenoviruses, CreERT2, Genetic manipulation, Hypothalamus, Median eminence, TAT-Cre, Tanycytes
Pubmed
Web of science
Open Access
Yes
Create date
10/08/2021 13:15
Last modification date
13/08/2021 6:39
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