Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles?

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_5F4C94BAD521
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles?
Journal
Journal of Infectious Diseases
Author(s)
Fontas  E., van Leth  F., Sabin  C. A., Friis-Moller  N., Rickenbach  M., d'Arminio Monforte  A., Kirk  O., Dupon  M., Morfeldt  L., Mateu  S., Petoumenos  K., El-Sadr  W., de Wit  S., Lundgren  J. D., Pradier  C., Reiss  P.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
03/2004
Volume
189
Number
6
Pages
1056-74
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar 15
Abstract
Levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c), as well as the TC:HDL-c ratio, were compared in patients receiving different antiretroviral therapy regimens. Patients receiving first-line regimens including protease inhibitors (PIs) had higher TC and TG levels and TC : HDL-c ratios than did antiretroviral-naive patients; patients receiving 2 PIs had higher levels of each lipid. Ritonavir-containing regimens were associated with higher TC and TG levels and TC : HDL-c ratios than were indinavir-containing regimens; however, receipt of nelfinavir was associated with reduced risk of lower HDL-c levels, and receipt of saquinavir was associated with lower TC : HDL-c ratios. Patients receiving nonnucleoside reverse-transcriptase inhibitors had higher levels of TC and LDL-c than did antiretroviral-naive patients, although the risk of having lower HDL-c levels was lower than that in patients receiving a single PI. Efavirenz was associated with higher levels of TC and TG than was nevirapine.
Keywords
Adult Anti-HIV Agents/administration & dosage/*adverse effects Cholesterol/blood Coronary Disease/etiology Cross-Sectional Studies Drug Therapy, Combination Female HIV Infections/blood/*drug therapy Humans Indinavir/adverse effects Lipids/*blood Logistic Models Male Prospective Studies Ritonavir/adverse effects Saquinavir/adverse effects Triglycerides/blood
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 9:52
Last modification date
25/09/2019 7:09
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