Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.

Details

Serval ID
serval:BIB_5F34FDE8F989
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.
Journal
American Journal of Human Genetics
Author(s)
Ganesh S.K., Chasman D.I., Larson M.G., Guo X., Verwoert G., Bis J.C., Gu X., Smith A.V., Yang M.L., Zhang Y., Ehret G., Rose L.M., Hwang S.J., Papanicolau G.J., Sijbrands E.J., Rice K., Eiriksdottir G., Pihur V., Ridker P.M., Vasan R.S., Newton-Cheh C., Raffel L.J., Raffel L.J., Amin N., Rotter J.I., Liu K., Launer L.J., Xu M., Caulfield M., Morrison A.C., Johnson A.D., Vaidya D., Dehghan A., Li G., Bouchard C., Harris T.B., Zhang H., Boerwinkle E., Siscovick D.S., Gao W., Uitterlinden A.G., Rivadeneira F., Hofman A., Willer C.J., Franco O.H., Huo Y., Witteman J.C., Munroe P.B., Gudnason V., Palmas W., van Duijn C., Fornage M., Levy D., Psaty B.M., Chakravarti A.
Working group(s)
Global Blood Pressure Genetics Consortium
Contributor(s)
Newton-Cheh C., Johnson T., Gateva V., Tobin MD., Bochud M., Coin L., Najjar SS., Zhao JH., Heath SC., Eyheramendy S., Papadakis K., Voight BF., Scott LJ., Zhang F., Farrall M., Tanaka T., Wallace C., Chambers JC., Khaw KT., Nilsson P., van der Harst P., Polidoro S., Grobbee DE., Onland-Moret NC., Bots ML., Wain LV., Elliott KS., Teumer A., Luan£££Jian'an£££ J. , Lucas G., Kuusisto J., Burton PR., Hadley D., McArdle WL., Brown M., Dominiczak A., Newhouse SJ., Samani NJ., Webster J., Zeggini E., Beckmann JS., Bergmann S., Lim N., Song K., Vollenweider P., Waeber G., Waterworth DM., Yuan X., Groop L., Orho-Melander M., Allione A., Di Gregorio A., Guarrera S., Panico S., Ricceri F., Romanazzi V., Sacerdote C., Vineis P., Barroso£££Inês£££ I. , Sandhu MS., Luben RN., Crawford GJ., Jousilahti P., Perola M., Boehnke M., Bonnycastle LL., Collins FS., Jackson AU., Mohlke KL., Stringham HM., Valle TT., Willer CJ., Bergman RN., Morken MA., Döring A., Gieger C., Illig T., Meitinger T., Org E., Pfeufer A., Wichmann HE., Kathiresan S., Marrugat J., O'Donnell CJ., Schwartz SM., Siscovick DS., Subirana I., Freimer NB., Hartikainen AL., McCarthy MI., O'Reilly PF., Peltonen L., Pouta A., de Jong PE. , Snieder H., van Gilst WH. , Clarke R., Goel A., Hamsten A., Peden JF., Seedorf U., Syvänen AC., Tognoni G., Lakatta EG., Sanna S., Scheet P., Schlessinger D., Scuteri A., Dörr M., Ernst F., Felix SB., Homuth G., Lorbeer R., Reffelmann T., Rettig R., Völker U., Galan P., Gut IG., Hercberg S., Lathrop GM., Zeleneka D., Deloukas P., Soranzo N., Williams FM., Zhai G., Salomaa V., Laakso M., Elosua R., Forouhi NG., Völzke H., Uiterwaal CS., van der Schouw YT. , Numans ME., Matullo G., Navis G., Berglund G., Bingham SA., Kooner JS., Paterson AD., Connell JM., Bandinelli S., Ferrucci L., Watkins H., Spector TD., Tuomilehto J., Altshuler D., Strachan DP., Laan M., Meneton P., Wareham NJ., Uda M., Jarvelin MR., Mooser V., Melander O., Loos RJ., Elliott P., Abecasis GR., Caulfield M., Munroe PB.
ISSN
1537-6605 (Electronic)
ISSN-L
0002-9297
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
95
Number
1
Pages
49-65
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs1275988, near KCNK3), DBP at 2q11.2 (rs7599598, in FER1L5), and PP at 6p21 (rs10948071, near CRIP3) and 7p13 (rs2949837, near IGFBP3). Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association studies. Using LTA analysis, we identified genetic loci influencing BP. LTA might be one way of increasing the power of genetic associations for continuous traits in extant samples for other phenotypes that are measured serially over time.
Keywords
Blood Pressure/genetics, Genome-Wide Association Study, Humans, Longitudinal Studies, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci
Pubmed
Web of science
Open Access
Yes
Create date
02/10/2014 13:38
Last modification date
20/08/2019 14:16
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