Anti-Nogo-A Antibody Treatment Promotes Recovery of Manual Dexterity after Unilateral Cervical Lesion in Adult Primates--re-examination and Extension of Behavioral Data.

Details

Serval ID
serval:BIB_5F30A2BC9176
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Anti-Nogo-A Antibody Treatment Promotes Recovery of Manual Dexterity after Unilateral Cervical Lesion in Adult Primates--re-examination and Extension of Behavioral Data.
Journal
European Journal of Neuroscience
Author(s)
Freund Patrick, Schmidlin Eric, Wannier Thierry, Bloch Jocelyne, Mir Anis, Schwab Martin E., Rouiller Eric M.
ISSN
1460-9568[electronic]
Publication state
Published
Issued date
2009
Volume
29
Number
5
Pages
983-996
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary outcome measures from the same manual dexterity test. Thirteen adult monkeys were studied; seven received an anti-Nogo-A antibody whereas a control antibody was infused into the other monkeys. Monkeys were trained to perform the modified Brinkman board task requiring opposition of index finger and thumb to grasp food pellets placed in vertically and horizontally oriented slots. Two parameters were quantified before and following spinal cord injury: (i) the standard 'score' as defined by the number of pellets retrieved within 30 s from the two types of slots; (ii) the newly introduced 'contact time' as defined by the duration of digit contact with the food pellet before successful retrieval. After lesion the hand was severely impaired in all monkeys; this was followed by progressive functional recovery. Remarkably, anti-Nogo-A antibody-treated monkeys recovered faster and significantly better than control antibody-treated monkeys, considering both the score for vertical and horizontal slots (Mann-Whitney test: P = 0.05 and 0.035, respectively) and the contact time (P = 0.008 and 0.005, respectively). Detailed analysis of the lesions excluded the possibility that this conclusion may have been caused by differences in lesion properties between the two groups of monkeys.
Keywords
Animals, Antibodies/therapeutic use, Behavior, Animal/drug effects, Cervical Vertebrae/pathology, Female, Functional Laterality/drug effects, Functional Laterality/physiology, Macaca fascicularis, Macaca mulatta, Male, Myelin Proteins/immunology, Psychomotor Performance/drug effects, Recovery of Function/drug effects, Recovery of Function/physiology, Spinal Cord Injuries/drug therapy, Spinal Cord Injuries/pathology, Statistics, Nonparametric, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2010 11:25
Last modification date
20/08/2019 14:16
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