Sound recognition and localization in man: specialized cortical networks and effects of acute circumscribed lesions.

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Serval ID
serval:BIB_5F12F9D87D9C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sound recognition and localization in man: specialized cortical networks and effects of acute circumscribed lesions.
Journal
Experimental Brain Research
Author(s)
Adriani M., Maeder P., Meuli R., Thiran A.B., Frischknecht R., Villemure J.G., Mayer J., Annoni J.M., Bogousslavsky J., Fornari E., Thiran J.P., Clarke S.
ISSN
0014-4819 (Print)
ISSN-L
0014-4819
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
153
Number
4
Pages
591-604
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Functional imaging studies have shown that information relevant to sound recognition and sound localization are processed in anatomically distinct cortical networks. We have investigated the functional organization of these specialized networks by evaluating acute effects of circumscribed hemispheric lesions. Thirty patients with a primary unilateral hemispheric lesion, 15 with right-hemispheric damage (RHD) and 15 with left-hemispheric damage (LHD), were evaluated for their capacity to recognise environmental sounds, to localize sounds in space and to perceive sound motion. One patient with RHD and 2 with LHD had a selective deficit in sound recognition; 3 with RHD a selective deficit in sound localization; 2 with LHD a selective deficit in sound motion perception; 4 with RHD and 3 with LHD a combined deficit of sound localization and motion perception; 2 with RHD and 1 with LHD a combined deficit of sound recognition and motion perception; and 1 with LHD a combined deficit of sound recognition, localization and motion perception. Five patients with RHD and 6 with LHD had normal performance in all three domains. Deficient performance in sound recognition, sound localization and/or sound motion perception was always associated with a lesion that involved the shared auditory structures and the specialized What and/or Where networks, while normal performance was associated with lesions within or outside these territories. Thus, damage to regions known to be involved in auditory processing in normal subjects is necessary, but not sufficient for a deficit to occur. Lesions of a specialized network was not always associated with the corresponding deficit. Conversely, specific deficits tended not be associated predominantly with lesions of the corresponding network; e.g. deficits in auditory spatial tasks were observed in patients whose lesions involved to a larger extent the shared auditory structures and the specialized What network than the specialized Where network, and deficits in sound recognition in patients whose lesions involved mostly the shared auditory structures and to a varying degree the specialized What network. The human auditory cortex consists of functionally defined auditory areas, whose intrinsic organization is currently not understood. In particular, areas involved in the What and Where pathways can be conceived as: (1) specialized regions, in which lesions cause dysfunction limited to the damaged part; observed deficits should be then related to the specialization of the damaged region and their magnitude to the extent of the damage; or (2) specialized networks, in which lesions cause dysfunction that may spread over the two specialized networks; observed deficits may then not be related to the damaged region and their magnitude not proportional to the extent of the damage. Our results support strongly the network hypothesis.
Keywords
Acute Disease, Adolescent, Adult, Aged, Auditory Perception/physiology, Brain Mapping, Cerebral Cortex/pathology, Cerebral Cortex/physiopathology, Cerebral Infarction/pathology, Cerebral Infarction/physiopathology, Female, Functional Laterality/physiology, Humans, Language Development Disorders/pathology, Language Development Disorders/physiopathology, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Motion Perception/physiology, Nerve Net/pathology, Nerve Net/physiopathology, Neural Pathways/pathology, Neural Pathways/physiopathology, Neuropsychological Tests, Sound Localization/physiology, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
11/04/2008 8:23
Last modification date
01/10/2019 6:18
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