Nicotine gum treatment before smoking cessation: a randomized trial.

Details

Serval ID
serval:BIB_5F0FE0374320
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nicotine gum treatment before smoking cessation: a randomized trial.
Journal
Archives of Internal Medicine
Author(s)
Etter J.F., Huguelet P., Perneger T.V., Cornuz J.
ISSN
1538-3679[electronic]
Publication state
Published
Issued date
2009
Volume
169
Number
11
Pages
1028-1034
Language
english
Abstract
BACKGROUND: New ways of improving the efficacy of nicotine therapy need to be explored. We tested whether starting nicotine polacrilex gum treatment 4 weeks before the quit date improved smoking abstinence rates compared with starting treatment on the quit date. METHODS: An open randomized trial of 314 daily smokers (mean, 23.7 cigarettes/d) enrolled through the Internet and by physicians in Switzerland from November 2005 to January 2007. In the precessation treatment group, participants received nicotine polacrilex gum (4 mg, unflavored) by mail for 4 weeks before and 8 weeks after their target quit date, and they were instructed to decrease their cigarette consumption by half before quitting. In the usual care group, participants received the same nicotine gum for 8 weeks after their quit date and were instructed to quit abruptly. Instructions were limited to a booklet sent by mail and access to a smoking cessation Web site. Results are expressed as self-reported abstinence rates at the end of treatment and as biochemically verified smoking abstinence (cotinine plus carbon monoxide) after 12 months. RESULTS: Eight weeks after the target quit date, self-reported 4-week abstinence rates were 41.6% in the precessation treatment group and 44.4% in the usual care group (P = .61). One year after the target quit date, biochemically verified 4-week smoking abstinence rates were 20.8% in the precessation treatment group and 19.4% in the usual care group (P = .76). CONCLUSION: Starting nicotine gum treatment 4 weeks before the target quit date was no more effective than starting treatment on the quit date.
Keywords
Bupropion/therapeutic use, Chewing Gum, Humans, Nicotine/administration & dosage, Nicotine/analogs & derivatives, Polymethacrylic Acids/administration & dosage, Polyvinyls/administration & dosage, Smoking Cessation/methods, Weight Gain
Pubmed
Web of science
Open Access
Yes
Create date
04/09/2009 12:44
Last modification date
20/08/2019 14:16
Usage data