Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.

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Serval ID
serval:BIB_5EEB7A8C68D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.
Journal
Scientific reports
Author(s)
Abdel-Sayed P., Kaeppeli A., Siriwardena T., Darbre T., Perron K., Jafari P., Reymond J.L., Pioletti D.P., Applegate L.A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
25/02/2016
Peer-reviewed
Oui
Volume
6
Pages
22020
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3RL, able to kill multi-drug resistant P. aeruginosa, have been previously developed. The combination of these dendrimers with a class of biological bandages made of progenitor skin cells, which secrete growth factors, could positively impact wound-healing processes. However, polycations are known to be used as anti-angiogenic agents for tumor suppression. Since, neovascularization is pivotal in the healing of deep burn-wounds, the use of anti-microbial dendrimers may thus hinder the healing processes. Surprisingly, we have seen in this study that G3KL and G3RL dendrimers can have angiogenic effects. Moreover, we have shown that a dendrimer concentration ranging between 50 and 100 μg/mL in combination with the biological bandages can suppress bacterial growth without altering cell viability up to 5 days. These results show that antimicrobial dendrimers can be used in combination with biological bandages and could potentially improve the healing process with an enhanced angiogenesis.
Keywords
Angiogenesis Inducing Agents/pharmacology, Anti-Infective Agents/pharmacology, Bandages, Burns/complications, Cell Survival/drug effects, Dendrimers, Fibroblasts/drug effects, Fibroblasts/metabolism, Humans, Neovascularization, Physiologic/drug effects, Pseudomonas aeruginosa/drug effects, Wound Healing, Wound Infection/drug therapy, Wound Infection/microbiology
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2016 18:24
Last modification date
06/09/2020 5:23
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