Lithium augmentation in depressive patients not responding to selective serotonin reuptake inhibitors

Details

Serval ID
serval:BIB_5E527C96FC38
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lithium augmentation in depressive patients not responding to selective serotonin reuptake inhibitors
Journal
Pharmacopsychiatry
Author(s)
Zullino Daniele Fabio, Baumann Pierre
ISSN
0176-3679
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
34
Number
4
Pages
119-125
Language
english
Notes
AN - Peer Reviewed Journal: 2001-11123-001 LG - English Conference Proceedings/Symposia. Literature Review CF - ECNP Meeting, 1997, Vienna PT - Peer Reviewed Journal RF - Adli, M., Bschor, T., Canata, B., Dopfmer, S., & Bauer, M. (1998). Lithium in der Behandlung der akuten Depression. Fortschr Neurol Psychiat 1998; 66: 435- 441 Institution : Dept U de Psychiatrie Adulte, Unite de Biochimie et Psychopharmacologie, Prilly-Lausanne, Switzerland SAPHIRID:48208
Abstract
Reviews current literature on lithium augmentation (LA) in patients not responding to selective serotonin reuptake inhibitors (SSRIs) giving some recommendations at the end. A significant proportion of depressive patients do not respond to a 1st antidepressive treatment independently of the class of drug used. During the last 10 yrs, there have been several cae reports published about open and controlled studies on the use of LA in patients who were non-responders to SSRIs, including citalopram, fluoxetine, paroxetine and sertraline. The main underlying hypothesis is a synergistic effect between SSRIs and lithium, which both act on serotonergic neurotransmission. The available studies vary considerably in methodology. There are insufficient results available to confirm a rapid improvement, but most studies show substantial effects after 1-2 wkS, and some after 6 wks. There is as yet no more clear evidence for a pharmacokinetic inter action between lithium and SSRIs with pharmacodynamic consequences. (PsycINFO Database Record (c) 2004 APA, all rights reserved)
Pubmed
Web of science
Create date
10/03/2008 11:37
Last modification date
20/08/2019 15:16
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