Tracing the associations between sex, the atypical and the combined atypical-melancholic depression subtypes: A path analysis.

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Serval ID
serval:BIB_5E34A7209708
Type
Article: article from journal or magazin.
Collection
Publications
Title
Tracing the associations between sex, the atypical and the combined atypical-melancholic depression subtypes: A path analysis.
Journal
Journal of Affective Disorders
Author(s)
Rodgers S., Vandeleur C.L., Ajdacic-Gross V., Aleksandrowicz A.A., Strippoli M.P., Castelao E., Glaus J., Lasserre A.M., Müller M., Rössler W., Angst J., Preisig M.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
190
Pages
807-818
Language
english
Abstract
BACKGROUND: Numerous studies have examined determinants leading to preponderance of women in major depressive disorder (MDD), which is particularly accentuated for the atypical depression subtype. It is thus of interest to explore the specific indirect effects influencing the association between sex and established depression subtypes.
METHODS: The data of 1624 subjects with a lifetime diagnosis of MDD derived from the population-based PsyCoLaus data were used. An atypical (n=256), a melancholic (n=422), a combined atypical and melancholic features subtype (n=198), and an unspecified MDD group (n=748) were constructed according to the DSM-IV specifiers. Path models with direct and indirect effects were applied to the data.
RESULTS: Partial mediation of the female-related atypical and combined atypical-melancholic depression subtypes was found. Early anxiety disorders and high emotion-orientated coping acted as mediating variables between sex and the atypical depression subtype. In contrast, high Body Mass Index (BMI) served as a suppression variable, also concerning the association between sex and the combined atypical-melancholic subtype. The latter association was additionally mediated by an early age of MDD onset and early/late anxiety disorders.
LIMITATIONS: The use of cross-sectional data does not allow causal conclusions.
CONCLUSIONS: This is the first study that provides evidence for a differentiation of the general mechanisms explaining sex differences of overall MDD by depression subtypes. Determinants affecting the pathways begin early in life. Since some of them are primarily of behavioral nature, the present findings could be a valuable target in mental health care.
Keywords
Adult, Age of Onset, Anxiety Disorders/epidemiology, Body Mass Index, Cross-Sectional Studies, Depression/classification, Depressive Disorder, Major/epidemiology, Depressive Disorder, Major/psychology, Female, Humans, Male, Middle Aged, Sex Distribution, Switzerland/epidemiology
Pubmed
Web of science
Create date
08/12/2015 16:16
Last modification date
27/09/2019 8:57
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