Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results

Details

Serval ID
serval:BIB_5E1E30F116BF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results
Journal
British Journal of Cancer
Author(s)
Ris  H. B., Altermatt  H. J., Inderbitzi  R., Hess  R., Nachbur  B., Stewart  J. C., Wang  Q., Lim  C. K., Bonnett  R., Berenbaum  M. C., Althaus  U.
ISSN
0007-0920 (Print)
Publication state
Published
Issued date
12/1991
Volume
64
Number
6
Pages
1116-20
Notes
Journal Article --- Old url value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1764375 --- Old month value: Dec
Abstract
Four patients underwent intraoperative photodynamic therapy after surgery with meso-tetra-(hydroxyphenyl)-chlorin (mTHPC-PDT) for diffuse malignant mesothelioma. Preliminary procedures were performed in two patients in order to establish the efficacy of mTHPC-PDT and to optimise its tumoricidal effect. The tumoricidal effect was related to the mTHPC dose, light dose and the time interval between sensitation and activation. 0.3 mg kg-1 mTHPC activated after 48 h with 10 Joules cm-2 of non-thermal laser light at 650 nm resulted in a 10 mm deep tumour infarction, due to tumour vessel necrosis and thrombosis. The mTHPC tissue concentration was up to 14 times higher in the tumour than in normal tissues. Skin photosensitivity was mild, dose dependent and occurred 3 to 10 days after administration of mTHPC. According to the results obtained, intraoperative mTHPC-PDT was performed following pleuropneumonectomy in two, pleurectomy and lobectomy in one and pleurectomy in one patient. Ten Joules cm-2 were delivered to the diaphragm and the costophrenic sulcus and 5 Joules cm-2 to the remaining thoracic cavity. The postoperative course was marked by loss of appetite, fluid retention, hypoproteinemia and severe chest pain. One patient succumbed from aspiration pneumonia. The remaining patients developed no neural or vascular alterations and no bronchial stump insufficiency during follow-up. mTHPC-PDT following surgical tumour resection deserves further evaluation in good risk patients with diffuse malignant mesothelioma.
Keywords
Combined Modality Therapy Evaluation Studies Humans Male Mesoporphyrins/*therapeutic use Mesothelioma/*drug therapy/surgery Middle Aged Photochemotherapy/*methods Radiation-Sensitizing Agents/*therapeutic use
Pubmed
Web of science
Create date
29/01/2008 13:00
Last modification date
20/08/2019 14:16
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