Genome Editing for CNS Disorders.

Details

Ressource 1Download: Duarte et al. 2020.pdf (1731.15 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_5E153956DF3C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genome Editing for CNS Disorders.
Journal
Frontiers in neuroscience
Author(s)
Duarte F., Déglon N.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
14
Pages
579062
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Central nervous system (CNS) disorders have a social and economic burden on modern societies, and the development of effective therapies is urgently required. Gene editing may prevent or cure a disease by inducing genetic changes at endogenous loci. Genome editing includes not only the insertion, deletion or replacement of nucleotides, but also the modulation of gene expression and epigenetic editing. Emerging technologies based on ZFs, TALEs, and CRISPR/Cas systems have extended the boundaries of genome manipulation and promoted genome editing approaches to the level of promising strategies for counteracting genetic diseases. The parallel development of efficient delivery systems has also increased our access to the CNS. In this review, we describe the various tools available for genome editing and summarize in vivo preclinical studies of CNS genome editing, whilst considering current limitations and alternative approaches to overcome some bottlenecks.
Keywords
CNS, CRISPR/Cas, TALEs, ZFs, genome editing
Pubmed
Web of science
Open Access
Yes
Create date
27/10/2020 18:08
Last modification date
25/11/2020 7:25
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