Contribution of major cardiovascular risk factors to familial premature coronary artery disease: the GENECARD project.

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Serval ID
serval:BIB_5E069A9E589B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Contribution of major cardiovascular risk factors to familial premature coronary artery disease: the GENECARD project.
Journal
Journal of the American College of Cardiology
Author(s)
Jomini V., Oppliger-Pasquali S., Wietlisbach V., Rodondi N., Jotterand V., Paccaud F., Darioli R., Nicod P., Mooser V.
ISSN
0735-1097
ISSN-L
0735-1097
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
40
Number
4
Pages
676-684
Language
english
Abstract
OBJECTIVES: This study was designed to assess the prevalence of major cardiovascular risk factors in familial premature coronary artery disease (P-CAD), affecting two or more siblings within one sibship. BACKGROUND: Premature CAD has a genetic component. It remains to be established whether familial P-CAD is due to genes acting independently from major cardiovascular risk factors. METHODS: We recruited 213 P-CAD survivors from 103 sibships diagnosed before age <or=50 (men) or <or=55 (women) years old. Hypertension, hypercholesterolemia, obesity, and smoking were documented at the time of the event in 163 patients (145 men and 18 women). Each patient was compared with two individuals of the same age and gender, diagnosed with sporadic (nonfamilial) P-CAD, and three individuals randomly sampled from the general population. RESULTS: Compared with the general population, patients with sporadic P-CAD had a higher prevalence of hypertension (29% vs. 14%, p < 0.001), hypercholesterolemia (54% vs. 33%, p < 0.001), obesity (20% vs. 13%, p < 0.01), and smoking (76% vs. 39%, p < 0.001). These risk factors were equally or even more prevalent in patients with familial P-CAD (43% [p < 0.05 vs. sporadic P-CAD], 58% [p = 0.07], 21% and 72%, respectively). Overall, only 7 (4%) of 163 of patients with familial P-CAD and 22 (7%) of 326 of patients with sporadic P-CAD had none of these conditions, as compared with 167 (34%) of 489 patients in the general population. CONCLUSIONS: Classic, remediable risk factors are highly prevalent in patients with familial P-CAD. Accordingly, a major contribution of genes acting in the absence of these risk factors is unlikely.
Keywords
Adult, Age of Onset, Cardiovascular Diseases, Coronary Disease, Female, Humans, Hypercholesterolemia, Hypertension, Male, Middle Aged, Myocardial Infarction, Obesity, Pedigree, Prevalence, Risk Factors, Smoking
Pubmed
Web of science
Open Access
Yes
Create date
14/03/2008 10:20
Last modification date
20/08/2019 14:16
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