Induzione dell'ovulazione con somministrazione pulsatile intravenosa di Gn-RH in pazienti con amenorrea ipotalamica. [Ovulation induction by pulsatile intravenous administration of Gn-RH to patients with hypothalamic amenorrhea]

Details

Serval ID
serval:BIB_5DC3E979393B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Induzione dell'ovulazione con somministrazione pulsatile intravenosa di Gn-RH in pazienti con amenorrea ipotalamica. [Ovulation induction by pulsatile intravenous administration of Gn-RH to patients with hypothalamic amenorrhea]
Journal
Minerva Ginecologica
Author(s)
Dessole  S., Germond  M., Senn  A., Welti  H., De Grandi  P.
ISSN
0026-4784 (Print)
Publication state
Published
Issued date
03/1993
Volume
45
Number
3
Pages
71-6
Notes
English Abstract
Journal Article --- Old month value: Mar
Abstract
Intravenous pump administration (Zyklomat, Ferring) of GnRH (Lutrelef, Ferring) has been used to induce ovulation in 16 patients suffering from hypothalamic amenorrhea between January 1989 and December 1991. One to 6 cycles were performed for a total of 47 cycles. GnRH pulses were set at 20 micrograms/pulse every 90 min up during the follicular phase and decreased to 1 pulse/120 min during the 3-5 days following ovulation. Thereafter, the luteal phase was supported by 1000 IU HCG/48 h up to the end of the 5th week. Response to the treatment was monitored with seriC E2, P and LH and vaginal echography. Cycles (N = 3) were cancelled when E2 did not reach at least 0.25 nmol/l after 30 days. An E2 level > 0.8 nmol/l, associated with a mature follicle (> 20 mm), and the presence of a LH peak or an increased progesterone level were used to determine the day of ovulation. In case of normozoospermy (N = 9), sexual intercourse was recommended to the patients (27 cycles), whereas an intrauterine insemination was performed in case of a male factor (N = 7, 20 cycles). Results can be summarized as follows: 39 (83%) cycles were ovulatory and led to 9 (19%) clinical and 6 (13%) biochemical pregnancies. Five (8.5%) pregnancies aborted and 5 (11%) came to full term. After exclusion of the male factors, the pregnancy rate reaches 26%/initiated cycle, 28%/ovulatory cycle and 56%/patient. No patient developed a hyperstimulation syndrome or a multiple pregnancy. Three cycles (6.3%) were interrupted due to 2 superficial phlebitis and 1 pump failure.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult Amenorrhea/drug therapy/*etiology Female Gonadotropin-Releasing Hormone/*administration & dosage Humans Hypothalamus/physiopathology Infertility, Female/blood/drug therapy/etiology Infusions, Intravenous Ovulation Induction/*methods Pregnancy
Pubmed
Create date
25/01/2008 16:39
Last modification date
20/08/2019 15:15
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