Physical activity and fat-free mass during growth and in later life.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_5DB8BE09FB26
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Physical activity and fat-free mass during growth and in later life.
Journal
The American journal of clinical nutrition
Author(s)
Westerterp K.R., Yamada Y., Sagayama H., Ainslie P.N., Andersen L.F., Anderson L.J., Arab L., Baddou I., Bedu-Addo K., Blaak E.E., Blanc S., Bonomi A.G., Bouten CVC, Bovet P., Buchowski M.S., Butte N.F., Camps SGJA, Close G.L., Cooper J.A., Das S.K., Cooper R., Dugas L.R., Ekelund U., Entringer S., Forrester T., Fudge B.W., Goris A.H., Gurven M., Hambly C., El Hamdouchi A., Hoos M.B., Hu S., Joonas N., Joosen A.M., Katzmarzyk P., Kempen K.P., Kimura M., Kraus W.E., Kushner R.F., Lambert E.V., Leonard W.R., Lessan N., Martin C.K., Medin A.C., Meijer E.P., Morehen J.C., Morton J.P., Neuhouser M.L., Nicklas T.A., Ojiambo R.M., Pietiläinen K.H., Pitsiladis Y.P., Plange-Rhule J., Plasqui G., Prentice R.L., Rabinovich R.A., Racette S.B., Raichlen D.A., Ravussin E., Reynolds R.M., Roberts S.B., Schuit A.J., Sjödin A.M., Stice E., Urlacher S.S., Valenti G., Van Etten L.M., Van Mil E.A., Wells JCK, Wilson G., Wood B.M., Yanovski J., Yoshida T., Zhang X., Murphy-Alford A.J., Loechl C.U., Luke A.H., Pontzer H., Rood J., Schoeller D.A., Wong W.W., Speakman J.R.
Working group(s)
International Atomic Energy Agency Doubly Labeled Water database group
Contributor(s)
Branth S., Colbert L.H., De Bruin N.C., Dutman A.E., Elmståhl S., Fogelholm M., Harris T., Heijligenberg R., Jorgensen H.U., Larsson C.L., Rothenberg E.M., McCloskey M., Meijer G.A., Pannemans D.L., Schulz S., Van den Berg-Emons R., Van Gemert W.G., Wilhelmine W., Verboeket-van de V., Verbunt J.A., Philippaerts R.M., Subar A., Tanskanen M., Uauy R., Velthuis-Te Wierik E.J.
ISSN
1938-3207 (Electronic)
ISSN-L
0002-9165
Publication state
Published
Issued date
08/11/2021
Peer-reviewed
Oui
Volume
114
Number
5
Pages
1583-1589
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.
A study is presented of the association between FFM and physical activity in relation to age.
In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution.
PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM-adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: -0.2, 1.7 kg) and 1.0 kg (95% CI: -0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively.
If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.
Keywords
Adipose Tissue/metabolism, Adolescent, Adult, Aged, Aged, 80 and over, Body Composition, Child, Child, Preschool, Cross-Sectional Studies, Energy Metabolism, Exercise, Female, Humans, Male, Middle Aged, Young Adult, age, body composition, doubly labeled water, energy expenditure, physical activity level
Pubmed
Create date
04/10/2021 13:47
Last modification date
12/01/2022 8:10
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