Molecular Pathology of Well-Differentiated Gastro-entero-pancreatic Neuroendocrine Tumors.

Details

Serval ID
serval:BIB_5DA7857A7FA4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Molecular Pathology of Well-Differentiated Gastro-entero-pancreatic Neuroendocrine Tumors.
Journal
Endocrine pathology
Author(s)
Asa S.L., La Rosa S., Basturk O., Adsay V., Minnetti M., Grossman A.B.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Publication state
Published
Issued date
03/2021
Peer-reviewed
Oui
Volume
32
Number
1
Pages
169-191
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Well differentiated neuroendocrine tumors (NETs) arising in the gastrointestinal and pancreaticobiliary system are the most common neuroendocrine neoplasms. Studies of the molecular basis of these lesions have identified genetic mutations that predispose to familial endocrine neoplasia syndromes and occur both as germline events and in sporadic tumors. The mutations often involve epigenetic regulators rather than the oncogenes and tumor suppressors that are affected in other malignancies. Somatic copy number alterations and miRNAs have also been implicated in the development and progression of some of these tumors. The molecular profiles differ by location, but many are shared by tumors in other sites, including those outside the gastroenteropancreatic system. The approach to therapy relies on both the neuroendocrine nature of these tumors and the identification of specific alterations that can serve as targets for precision oncologic approaches.
Keywords
Gastrointestinal Neoplasms/genetics, Gastrointestinal Neoplasms/pathology, Humans, Neuroendocrine Tumors/genetics, Neuroendocrine Tumors/pathology, Oncogenes, Pancreatic Neoplasms/genetics, Pancreatic Neoplasms/pathology, Pathology, Molecular/methods, Stomach Neoplasms/genetics, Stomach Neoplasms/pathology, Gastrointestinal, Hepatobiliary, Molecular, Neuroendocrine tumor, Pancreatic
Pubmed
Web of science
Create date
19/01/2021 13:05
Last modification date
17/11/2021 6:39
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