Effects of amygdala-hippocampal stimulation on interictal epileptic discharges.

Details

Serval ID
serval:BIB_5D3D7EF0D2C0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of amygdala-hippocampal stimulation on interictal epileptic discharges.
Journal
Epilepsy Research
Author(s)
Tyrand R., Seeck M., Spinelli L., Pralong E., Vulliémoz S., Foletti G., Rossetti A.O., Allali G., Lantz G., Pollo C., Boëx C.
ISSN
1872-6844 (Electronic)
ISSN-L
0920-1211
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
99
Number
1-2
Pages
87-93
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Deep brain stimulation (DBS) of different nuclei is being evaluated as a treatment for epilepsy. While encouraging results have been reported, the effects of changes in stimulation parameters have been poorly studied. Here the effects of changes of pulse waveform in high frequency DBS (130Hz) of the amygdala-hippocampal complex (AH) are presented. These effects were studied on interictal epileptic discharge rates (IEDRs). AH-DBS was implemented with biphasic versus pseudo monophasic charge balanced pulses, in two groups of patients: six with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) and six with non lesional (NLES) temporal epilepsy. In patients with HS, IEDRs were significantly reduced with AH-DBS applied with biphasic pulses in comparison with monophasic pulse. IEDRs were significantly reduced in only two patients with NLES independently to stimulus waveform. Comparison to long-term seizure outcome suggests that IEDRs could be used as a neurophysiological marker of chronic AH-DBS and they suggest that the waveform of the electrical stimuli can play a major role in DBS. We concluded that biphasic stimuli are more efficient than pseudo monophasic pulses in AH-DBS in patients with HS. In patients with NLES epilepsy, other parameters relevant for efficacy of DBS remain to be determined.
Pubmed
Web of science
Create date
09/03/2012 18:13
Last modification date
20/08/2019 14:15
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