Epidemiology of inflammatory bowel disease: Is there a shift towards onset at a younger age?

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State: Public
Version: author
Serval ID
serval:BIB_5D35A5FBC94E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Epidemiology of inflammatory bowel disease: Is there a shift towards onset at a younger age?
Journal
Journal of Pediatric Gastroenterology and Nutrition
Author(s)
Braegger C.P., Ballabeni P., Rogler D., Vavricka S.R., Friedt M., Pittet V.
Working group(s)
Swiss IBD Cohort Study Group
Contributor(s)
Ballabeni P., Bauerfeind P., Beglinger C., Begré S., Bengoa J., Binek J., Boller D., Borovicka J., Braegger C., Bühr P., Brun P., Burnand B., Camara R., Criblez D., de Saussure P., Degen L., Delarive J., Ehmann T., Engelmann M., Wafa C., Felley C., Frei A., Frei R., Fried M., Friedt M., Froehlich F., Gallot- Lavallée S., Gerlach T., Geyer M., Girardin M., Goetze O., Haack H., Hediger S., Hengstler P., Heyland K., Janiak P., Juillerat P., Kessler Brondolo V., Knoblauch C., Kullak-Ublick GA., Manz M., Meier R., Meyen-berger C., Michetti P., Mottet C., Müller C., Müllhaupt B., Nicolet T., Nydegger A., Pache I., Piccoli F., Pilz J., Pittet V., Rentsch R., Rey JP., Rihs S., Rogler D., Rogler G., Sagmeister M., Sauter B., Schäppi M., Schaub N., Schibli S., Schoepfer A., Seibold F., Spalinger J., Stadler P., Steuerwald M., Straumann A., Sulz M., Thorens£££Joël£££ J. , Vader JP., Vavricka S., Vögtlin J., Von Känel R., Wachter G., Wermuth J., Wiesel P.
ISSN
1536-4801 (Electronic)
ISSN-L
0277-2116
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
53
Number
2
Pages
141-144
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVES: Increasing numbers of paediatric and adolescent patients with Crohn disease (CD) and ulcerative colitis (UC) are reported. To determine whether this observation is a consequence of a shift towards onset at a younger age, we analysed retrospective data from patients enrolled in the Swiss IBD Cohort Study (SIBDCS).
PATIENTS AND METHODS: The SIBDCS is a disease-based cohort in Switzerland, which collects retrospective and prospective data on a large sample of patients with inflammatory bowel disease (IBD). Patients, diagnosed from 1980, were stratified according to diagnosis of CD and UC. Age at disease onset (age at first symptoms and age at diagnosis) was analysed in relation to calendar year of disease onset. Data were extracted from physician and patient questionnaires. Linear regressions of age at disease onset by calendar year of disease onset adjusted by sex, country of birth, and education were performed.
RESULTS: Adjusted regression coefficients for CD and UC were significantly positive, that is, age at disease onset has increased with time. Male sex was associated with an increase in age at disease onset, and birth in Switzerland with a decrease. These associations were statistically significant.
CONCLUSIONS: The results from the SIBDCS do not support the hypothesis that disease onset of both CD and UC occur today at a younger age. On the contrary, our results show that there is a significant trend for age at disease onset occurring at an older age today as compared with recent decades. We conclude that the observation of increasing numbers of paediatric and adolescent patients with IBD is not caused by a trend towards disease onset at a younger age, but that this may rather be a consequence of the overall increasing incidence of these conditions.
Keywords
Adolescent, Adult, Age of Onset, Child, Cohort Studies, Crohn Disease/epidemiology, Female, Health Transition, Humans, Inflammatory Bowel Diseases/epidemiology, Male, Questionnaires, Reproducibility of Results, Retrospective Studies, Sex Factors, Switzerland/epidemiology, Young Adult
Pubmed
Web of science
Create date
28/07/2011 7:58
Last modification date
20/08/2019 15:15
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