Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics.

Details

Serval ID
serval:BIB_5D1F7941597C
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics.
Journal
Proteomics
Author(s)
Marino F.
ISSN
1615-9861 (Electronic)
ISSN-L
1615-9853
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
18
Number
12
Pages
e1800041
Language
english
Notes
Publication types: Journal Article ; Comment
Publication Status: ppublish
Abstract
Mass spectrometry (MS)-based immunopeptidomics has developed as one of the leading methodologies for comprehensive characterization of in vivo presented human leukocyte antigen (HLA)-bound peptides. Unveiling the identity of HLA-bound peptides derived from diseased cells is crucial to gain knowledge on the constitution of efficient disease-specific T cell responses. The HLA-presented peptidome reflects the status of the cellular proteome, hence disease-related aberrations of posttranslational modifications (PTMs) might lead to presentation of peptides harboring PTMs. Therefore, characterization of HLA-bound PTM peptides could shed light on their relevance in immune and disease processes. In this issue, Ramarathinam et al. investigate the presentation of HIV envelope (HIVenv) peptides bound to the HLA-B*57:01 allele. Among these peptides, the authors specifically focused on a kynurenine-modified peptide. To this end, they characterize the possible origin of the kynurenine modification, its effect on HLA binding affinity, stability, conformation within the complex, and its immunogenicity compared to the native counterpart.
Keywords
Antigen Presentation, Epitopes, HIV, HIV Antigens, HLA-B Antigens, Humans, HLA-B*57:01, Immunopeptidomics, Kynurenine
Pubmed
Web of science
Create date
08/03/2018 21:25
Last modification date
20/08/2019 15:15
Usage data