Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis.

Details

Serval ID
serval:BIB_5D18D907D885
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis.
Journal
Blood
Author(s)
Koch U., Wilson A., Cobas M., Kemler R., Macdonald H.R., Radtke F.
ISSN
0006-4971
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
111
Number
1
Pages
160-164
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self-renewal as well as in the development of B and T cells, conditional deletion of beta-catenin (which is considered to be essential for Wnt signaling) has no effect on hematopoiesis or lymphopoiesis. Here, we address whether this discrepancy can be explained by a redundant and compensatory function of gamma-catenin, a close homolog of beta-catenin. Unexpectedly, we find that combined deficiency of beta- and gamma-catenin in hematopoietic progenitors does not impair their ability to self-renew and to reconstitute all myeloid, erythroid, and lymphoid lineages, even in competitive mixed chimeras and serial transplantations. These results exclude an essential role for canonical Wnt signaling (as mediated by beta- and/or gamma-catenin) during hematopoiesis and lymphopoiesis.
Keywords
Animals, B-Lymphocytes/cytology, Bone Marrow Transplantation, Chimera, Female, Hematopoiesis/physiology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/physiology, Lymphopoiesis/physiology, Male, Mice, Mice, Mutant Strains, Pregnancy, T-Lymphocytes/cytology, beta Catenin/genetics, beta Catenin/metabolism, gamma Catenin/genetics, gamma Catenin/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:39
Last modification date
20/08/2019 14:15
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