Human herpesvirus-6, HHV-8 and parvovirus B19 after allogeneic hematopoietic cell transplant: the lesser-known viral complications.

Details

Serval ID
serval:BIB_5CFB1FC80B66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human herpesvirus-6, HHV-8 and parvovirus B19 after allogeneic hematopoietic cell transplant: the lesser-known viral complications.
Journal
Current opinion in infectious diseases
Author(s)
Kampouri E., Little J.S., Crocchiolo R., Hill J.A.
ISSN
1473-6527 (Electronic)
ISSN-L
0951-7375
Publication state
Published
Issued date
01/08/2024
Peer-reviewed
Oui
Volume
37
Number
4
Pages
245-253
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Viral infections continue to burden allogeneic hematopoietic cell transplant (HCT) recipients. We review the epidemiology, diagnosis, and management of human herpesvirus (HHV)-6, HHV-8 and parvovirus B19 following HCT.
Advances in HCT practices significantly improved outcomes but impact viral epidemiology: post-transplant cyclophosphamide for graft-versus-host disease prevention increases HHV-6 reactivation risk while the impact of letermovir for CMV prophylaxis - and resulting decrease in broad-spectrum antivirals - is more complex. Beyond the well established HHV-6 encephalitis, recent evidence implicates HHV-6 in pneumonitis. Novel less toxic therapeutic approaches (brincidofovir, virus-specific T-cells) may enable preventive strategies in the future. HHV-8 is the causal agent of Kaposi's sarcoma, which is only sporadically reported after HCT, but other manifestations are possible and not well elucidated. Parvovirus B19 can cause severe disease post-HCT, frequently manifesting with anemia, but can also be easily overlooked due to lack of routine screening and ambiguity of manifestations.
Studies should establish the contemporary epidemiology of HHV-6, and other more insidious viruses, such as HHV-8 and parvovirus B19 following HCT and should encompass novel cellular therapies. Standardized and readily available diagnostic methods are key to elucidate epidemiology and optimize preventive and therapeutic strategies to mitigate the burden of infection.
Keywords
Humans, Hematopoietic Stem Cell Transplantation/adverse effects, Herpesvirus 8, Human, Parvovirus B19, Human/isolation & purification, Herpesvirus 6, Human, Parvoviridae Infections/epidemiology, Parvoviridae Infections/diagnosis, Antiviral Agents/therapeutic use, Roseolovirus Infections/epidemiology, Roseolovirus Infections/virology, Roseolovirus Infections/diagnosis, Transplantation, Homologous/adverse effects, Herpesviridae Infections/epidemiology, Herpesviridae Infections/virology
Pubmed
Create date
13/05/2024 14:32
Last modification date
02/07/2024 8:42
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