A new formula for calculating standard liver volume for living donor liver transplantation without using body weight.

Details

Serval ID
serval:BIB_5CED910CA318
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A new formula for calculating standard liver volume for living donor liver transplantation without using body weight.
Journal
Journal of Hepatology
Author(s)
Kokudo T., Hasegawa K., Uldry E., Matsuyama Y., Kaneko J., Akamatsu N., Aoki T., Sakamoto Y., Demartines N., Sugawara Y., Kokudo N., Halkic N.
ISSN
1600-0641 (Electronic)
ISSN-L
0168-8278
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
63
Number
4
Pages
848-854
Language
english
Abstract
BACKGROUND & AIMS: The standard liver volume (SLV) is widely used in liver surgery, especially for living donor liver transplantation (LDLT). All the reported formulas for SLV use body surface area or body weight, which can be influenced strongly by the general condition of the patient.
METHODS: We analyzed the liver volumes of 180 Japanese donor candidates and 160 Swiss patients with normal livers to develop a new formula. The dataset was randomly divided into two subsets, the test and validation sample, stratified by race. The new formula was validated using 50 LDLT recipients.
RESULTS: Without using body weight-related variables, age, thoracic width measured using computed tomography, and race independently predicted the total liver volume (TLV). A new formula: 203.3-(3.61×age)+(58.7×thoracic width)-(463.7×race [1=Asian, 0=Caucasian]), most accurately predicted the TLV in the validation dataset as compared with any other formulas. The graft volume for LDLT was correlated with the postoperative prothrombin time, and the graft volume/SLV ratio calculated using the new formula was significantly better correlated with the postoperative prothrombin time than the graft volume/SLV ratio calculated using the other formulas or the graft volume/body weight ratio.
CONCLUSIONS: The new formula derived using the age, thoracic width and race predicted both the TLV in the healthy patient group and the SLV in LDLT recipients more accurately than any other previously reported formulas.
Pubmed
Web of science
Create date
19/10/2015 13:32
Last modification date
20/08/2019 15:15
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