p27(kip1) immunoreactivity correlates with long-term survival in pleural malignant mesothelioma.

Details

Serval ID
serval:BIB_5CE9CAC820B8
Type
Article: article from journal or magazin.
Collection
Publications
Title
p27(kip1) immunoreactivity correlates with long-term survival in pleural malignant mesothelioma.
Journal
Cancer
Author(s)
Bongiovanni M., Cassoni P., De Giuli P., Viberti L., Cappia S., Ivaldi C., Chiusa L., Bussolati G.
ISSN
0008-543X (Print)
ISSN-L
0008-543X
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
92
Number
5
Pages
1245-1250
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
BACKGROUND: Pleural malignant mesothelioma (PMM) is a rare and highly aggressive tumor, whose development is strictly related to occupational exposure to asbestos. The prognosis of PMM is generally poor (median survival, 4-12 months), but a few have a relatively long survival. The objective of this study was to evaluate the use of the cell cycle-related proteins p27(kip1) and MIB-1 as prognostic indicators of survival in PMMs.
METHODS: Of 621 PMMs, the authors selected 27 cases with a relatively long-term survival (> 24 months) and a control group of 36 PMMs having a shorter (usual) survival (< 24 months).
RESULTS: The expression of the p27(kip1) was significantly higher in the long-term survival group compared with the control (short survival) group (81.41% vs. 31.94%; P < 0.0001). The PMMs of epithelioid histotype had a significantly higher p27(kip1) immunoreactivity compared with those of biphasic type (59.24% vs. 38.94%; P = 0.02). In agreement with the data in the literature, the proliferative activity (as detected by MIB-1 immunoreactivity) was significantly higher in short than long survival PMMs (43.53% vs. 14.11%; P < 0.0001) and in the biphasic histotype than in the epithelioid type (43.19% vs. 26.02%; P = 0.006).
CONCLUSIONS: The combined expression of high/low p27(kip1) and low/high Ki-67 values identified with 100% specificity and sensitivity long versus short survivors. p27(kip1) represents a reliable additional predictive factor for PMMs and a useful marker to identify patients having a more favorable prognosis.
Keywords
Adult, Aged, Antigens, Nuclear, Cell Cycle Proteins/metabolism, Cyclin-Dependent Kinase Inhibitor p27, Female, Humans, Immunohistochemistry, Ki-67 Antigen/metabolism, Male, Mesothelioma/metabolism, Mesothelioma/mortality, Middle Aged, Nuclear Proteins/metabolism, Pleural Neoplasms/metabolism, Pleural Neoplasms/mortality, Survival Analysis, Tumor Suppressor Proteins
Pubmed
Web of science
Create date
05/02/2015 15:07
Last modification date
20/08/2019 14:15
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