High prevalence of peripheral arterial disease in HIV-infected persons

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Serval ID
serval:BIB_5CCE9F67E8CA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High prevalence of peripheral arterial disease in HIV-infected persons
Journal
Clinical Infectious Diseases
Author(s)
Periard D., Cavassini M., Taffé P., Chevalley M., Senn L., Chapuis-Taillard C., de Vallière S., Hayoz D., Tarr P. E.
ISSN
1537-6591
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
46
Number
5
Pages
761-767
Language
english
Abstract
BACKGROUND: Atherosclerosis has been assessed in human immunodeficiency virus (HIV)-infected persons by using various methods. Peripheral arterial disease (PAD) has not been evaluated, however. We studied the cross-sectional prevalence of lower limb PAD in an HIV-infected population. METHODS: PAD was assessed using the Edinburgh Claudication Questionnaire and by measuring the systolic ankle-brachial blood pressure index (ABI) at rest and after exercise. Patients with PAD were further evaluated by duplex scan of lower limb arteries. RESULTS: Ninety-two consecutive HIV-infected patients were evaluated (23.9% women; mean age, 49.5 years; 61.9% current smokers). Claudication was reported by 15.2% of the patients. PAD was found in 20.7% of the patients: 9.8% had an abnormal ABI (<0.90) at rest, and 10.9% had normal ABI at rest but a >25% decrease after exercise. Of the patients with PAD, 84.2% were investigated with duplex scan, all of whom had atherosclerotic occlusions or stenoses of the iliac or femoral arteries. Age, diabetes, smoking, and low CD4+ T lymphocyte counts were identified as independent predictors of PAD. CONCLUSIONS: The prevalence of symptomatic and asymptomatic PAD is high in the HIV-infected population and is much higher than expected (prevalence in the general population, approximately 3% at 60 years). This study suggests the presence of an epidemic of PAD approximately 20 years earlier in the HIV-infected than in the general population. Larger epidemiological studies are needed to better define risk factors and to evaluate whether PAD is associated with increased mortality, as it is in the general population.
Keywords
Adult , Age Factors , Atherosclerosis , blood , Blood Pressure , Blood Pressure Determination , CD4 Lymphocyte Count , complications , Constriction,Pathologic , Cross-Sectional Studies , Diabetes Mellitus , diagnosis , epidemiology , Female , Femoral Artery , HIV Infections , Humans , Iliac Artery , Male , methods , Middle Aged , mortality , Patients , Peripheral Vascular Diseases , Prevalence , Prospective Studies , Questionnaires , Rest , Risk , Risk Factors , Smoking , Switzerland , ultrasonography
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 23:13
Last modification date
25/09/2019 7:09
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