The deleterious effect of admission hyperglycemia on survival and functional outcome in patients with intracerebral hemorrhage.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_5CC48FDB84DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The deleterious effect of admission hyperglycemia on survival and functional outcome in patients with intracerebral hemorrhage.
Journal
Stroke
ISSN
1524-4628 (Electronic)
ISSN-L
0039-2499
Publication state
Published
Issued date
01/2012
Peer-reviewed
Oui
Volume
43
Number
1
Pages
243-245
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
We aimed to evaluate the association between blood glucose (BG) levels at admission and both functional outcome at discharge and 1-month mortality after intracerebral hemorrhage (ICH).
All cases of first-ever ICH were identified from the population-based Stroke Registry of Dijon, France from 1985 to 2009. Clinical and radiological information was recorded. BG was measured at admission. Multivariate analyses were performed using logistic and Cox regression models. Multiple imputation was used as a sensitivity analysis.
We recorded 465 first-ever ICH. BG at admission was obtained in 416 patients (89.5%) with a median value of 6.92 mmol/L. In multivariate analyses, BG in the highest tertile (≥8.6 mmol/L) was an independent predictor of functional handicap (odds ratio, 2.51; 95% CI, 1.43-4.40; P=0.01) and 1-month mortality (hazard ratio, 2.51; 95% CI, 1.23-2.43; P=0.002). The results were consistent with those obtained from multiple imputation analyses.
Admission hyperglycemia is associated with poor functional recovery at discharge and 1-month mortality after ICH. These results suggest a need for trials that evaluate strategies to lower BG in acute ICH.
All cases of first-ever ICH were identified from the population-based Stroke Registry of Dijon, France from 1985 to 2009. Clinical and radiological information was recorded. BG was measured at admission. Multivariate analyses were performed using logistic and Cox regression models. Multiple imputation was used as a sensitivity analysis.
We recorded 465 first-ever ICH. BG at admission was obtained in 416 patients (89.5%) with a median value of 6.92 mmol/L. In multivariate analyses, BG in the highest tertile (≥8.6 mmol/L) was an independent predictor of functional handicap (odds ratio, 2.51; 95% CI, 1.43-4.40; P=0.01) and 1-month mortality (hazard ratio, 2.51; 95% CI, 1.23-2.43; P=0.002). The results were consistent with those obtained from multiple imputation analyses.
Admission hyperglycemia is associated with poor functional recovery at discharge and 1-month mortality after ICH. These results suggest a need for trials that evaluate strategies to lower BG in acute ICH.
Keywords
Aged, Aged, 80 and over, Blood Glucose, Cerebral Hemorrhage/complications, Cerebral Hemorrhage/mortality, Cerebral Hemorrhage/physiopathology, Female, Humans, Hyperglycemia/complications, Hyperglycemia/mortality, Hyperglycemia/physiopathology, Male, Middle Aged, Predictive Value of Tests, Prognosis, Recovery of Function/physiology, Survival Rate, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
22/08/2024 21:59
Last modification date
23/08/2024 9:34
Usage data
