Impact of iron supplementation on substantial unexplained fatigue in iron deficient but not anaemic menstruated women

Details

Serval ID
serval:BIB_5CA128C8CD9D
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Impact of iron supplementation on substantial unexplained fatigue in iron deficient but not anaemic menstruated women
Title of the conference
Swiss Medical Weekly
Author(s)
Favrat B, Avril L, Druais PL
Publisher
EMH Editores Mwedicorum Helveticorm, FMH Schwabe
Organization
Swiss Society of Infectious Diseases, the Swiss Sociate of Internal Medicine and the Swiss Respiratory Society
ISBN
1424-7860
Publication state
Published
Issued date
08/2009
Peer-reviewed
Oui
Editor
15th Wonca Europe Conference , 32e Congrès de la SSMG 
Volume
139
Series
Suppl 175 ; OP-262
Pages
76S
Language
english
Abstract
Aim: To determine the impact of iron therapy on the quality of life of non-anaemic iron-deficient women with substantial unexplained fatigue.
Methods: Double blind randomised placebo controlled trial in 198 women aged 18 to 53 and having a ferritin level <50 ng/mL, assigned to either oral ferrous sulphate (80 mg/day of elemental iron daily; n = 102) or placebo (n = 96) for 12 weeks, by 44 general practices in France. Main outcome measures: Level of fatigue, depression and anxiety, measured by a 24-item self-administered questionnaire. Level of fatigue was also assessed with a visual analogue scale.
Results: 171 (86.4%) women were eligible for efficacy analysis. Mean age, haemoglobin concentration, serum ferritin concentration, level of fatigue, depression, and anxiety were similar in both groups at baseline. Both groups were also similar for compliance and dropout rates. After 12 weeks, asthenia score decreased by −12.9 } 10.37 points (50.8%) in the iron group compared with -9.01 } 11.71 points (36.7%) in the placebo group (p = 0.02), whereas depression and anxiety scores, already low at inclusion, slightly decrease to the same extent in both groups. In an intention to treat analysis, by considering a responder to iron supplementation as having more than two points decrease on the fatigue 10-point visual analogue scale, iron group had 83,3% (85/102) responders vs. 69.8% (67/96) in the control group (p = 0.02). The number needed to treat to have a benefit was 7.
Conclusion: Iron supplementation is an efficient inexpensive approach to manage unexplained fatigue in non-anaemic iron-deficient women.
Create date
29/01/2010 16:31
Last modification date
20/08/2019 15:15
Usage data