The role of A-kinase anchoring proteins in cardiac oxidative stress.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_5BFC10C47572
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of A-kinase anchoring proteins in cardiac oxidative stress.
Journal
Biochemical Society transactions
Author(s)
Diviani D., Osman H., Delaunay M., Kaiser S.
ISSN
1470-8752 (Electronic)
ISSN-L
0300-5127
Publication state
Published
Issued date
31/10/2019
Peer-reviewed
Oui
Volume
47
Number
5
Pages
1341-1353
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Cardiac stress initiates a pathological remodeling process that is associated with cardiomyocyte loss and fibrosis that ultimately leads to heart failure. In the injured heart, a pathologically elevated synthesis of reactive oxygen species (ROS) is the main driver of oxidative stress and consequent cardiomyocyte dysfunction and death. In this context, the cAMP-dependent protein kinase (PKA) plays a central role in regulating signaling pathways that protect the heart against ROS-induced cardiac damage. In cardiac cells, spatiotemporal regulation of PKA activity is controlled by A-kinase anchoring proteins (AKAPs). This family of scaffolding proteins tether PKA and other transduction enzymes at subcellular microdomains where they can co-ordinate cellular responses regulating oxidative stress. In this review, we will discuss recent literature illustrating the role of PKA and AKAPs in modulating the detrimental impact of ROS production on cardiac function.
Keywords
A-kinase anchoring protein, cardiac remodeling, cardiomyocyte, cyclic AMP, protein kinase A
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 31003A_175838
Create date
04/01/2020 12:55
Last modification date
17/01/2020 6:26
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