A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.

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Version: Final published version
Serval ID
serval:BIB_5BEF45DA9A4E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.
Journal
Cell reports
Author(s)
Oberle S.G., Hanna-El-Daher L., Chennupati V., Enouz S., Scherer S., Prlic M., Zehn D.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
11/10/2016
Peer-reviewed
Oui
Volume
17
Number
3
Pages
627-635
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact the repertoire of T cells responding to new antigens is still largely unknown. We demonstrate that even a minimum epitope overlap between infections strongly increases the activation threshold and narrows the diversity of T cells recruited in response to new antigens. Thus, minimal cross-reactivity between infections can significantly impact the outcome of a subsequent immune response. Interestingly, we found that non-transferrable memory T cells are most effective in raising the activation threshold. Our findings have implications for designing vaccines and suggest that vaccines meant to target low-affinity T cells are less effective when they contain a strong CD8 T cell epitope that has previously been encountered.

Keywords
Adoptive Transfer, Animals, Antigen Presentation/immunology, CD8-Positive T-Lymphocytes/immunology, Coinfection/immunology, Communicable Diseases/immunology, Communicable Diseases/pathology, Epitopes, T-Lymphocyte/immunology, Immunologic Memory, Inflammation/pathology, Lymphocyte Activation/immunology, Mice, Inbred C57BL, T-Lymphocytes/immunology, T cell activation threshold, cytotoxic T cells, secondary immune responses, strength of TCR stimulation
Pubmed
Web of science
Open Access
Yes
Create date
19/10/2016 11:15
Last modification date
20/08/2019 14:14
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