Severe hyperlipidemia causes impaired renin-angiotensin system function in apolipoprotein E deficient mice.

Details

Serval ID
serval:BIB_5BB2BD57F6AA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Severe hyperlipidemia causes impaired renin-angiotensin system function in apolipoprotein E deficient mice.
Journal
Atherosclerosis
Author(s)
Mazzolai L., Korber M., Bouzourene K., Aubert J.F., Nussberger J., Stamenkovic I., Hayoz D.
ISSN
0021-9150
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
186
Number
1
Pages
86-91
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Dyslipidemia is a known risk factor for cardiovascular diseases and may associate with renal injury. Using mouse models with various degrees of hypercholesterolemia and hypertryliceridemia, we investigated the effects of lipids on the renin-angiotensin system (RAS). ApoE-/- mice were fed either a high fat diet (HF-ApoE-/-; mice developed hypertriglyceridemia and severe hypercholesterolemia) or regular chow (R-ApoE(-/-); mice developed less severe hypercholesterolemia only). Renal histopathology in the HF-ApoE-/- revealed massive lipid accumulation especially at the glomerular vascular pole. In these mice plasma renin concentration was significantly reduced (489+/-111 ng/(ml h) versus 1023+/-90 ng/(ml h) in R-ApoE-/- mice) and blood pressure was consequently significantly lower than in R-ApoE-/- (104+/-2 mmHg versus 115+/-2 mmHg, respectively). A model of renin-dependent renovascular hypertension (two-kidney, one clip) was generated and HF-ApoE-/- mice proved unable to increase renin secretion, and blood pressure, in response to diminished renal perfusion as compared to regular chow fed mice (665+/-90 ng/(ml h) versus 2393+/-372 ng/(ml h), respectively and 106+/-3 mmHg versus 140+/-2 mmHg, respectively). Hypertriglyceridemia and severe hypercholesterolemia are associated with renal lipid deposition and impaired renin secretion in ApoE-/- mice exposed to high fat diet. These observations further characterize the phenotype of this widely used mouse model and provide a rationale for the use of these mice to study lipid induced organ damage.
Keywords
Animals, Apolipoproteins E, Blood Pressure, Disease Models, Animal, Hyperlipidemias, Hypertension, Renal, Immunohistochemistry, Kidney, Mice, Mice, Inbred C57BL, Prognosis, Renin, Renin-Angiotensin System, Risk Factors
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 14:14
Usage data