The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network.

Details

Serval ID
serval:BIB_5B9F48AC4D7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network.
Journal
International Journal of Radiation Oncology, Biology, Physics
Author(s)
Pica A., Miller R., Villà S., Kadish S.P., Anacak Y., Abusaris H., Ozyigit G., Baumert B.G., Zaucha R., Haller G., Weber D.C.
ISSN
1879-355X[electronic]
Publication state
Published
Issued date
2009
Volume
74
Number
4
Pages
1114-1120
Language
english
Abstract
PURPOSE: The aim of this study was to assess the outcome of patients with primary spinal myxopapillary ependymoma (MPE). MATERIALS AND METHODS: Data from a series of 85 (35 females, 50 males) patients with spinal MPE were collected in this retrospective multicenter study. Thirty-eight (45%) underwent surgery only and 47 (55%) received postoperative radiotherapy (RT). Median administered radiation dose was 50.4 Gy (range, 22.2-59.4). Median follow-up of the surviving patients was 60.0 months (range, 0.2-316.6). RESULTS: The 5-year progression-free survival (PFS) was 50.4% and 74.8% for surgery only and surgery with postoperative low- (<50.4 Gy) or high-dose (>or=50.4 Gy) RT, respectively. Treatment failure was observed in 24 (28%) patients. Fifteen patients presented treatment failure at the primary site only, whereas 2 and 1 patients presented with brain and distant spinal failure only. Three and 2 patients with local failure presented with concomitant spinal distant seeding and brain failure, respectively. One patient failed simultaneously in the brain and spine. Age greater than 36 years (p = 0.01), absence of neurologic symptoms at diagnosis (p = 0.01), tumor size >or=25 mm (p = 0.04), and postoperative high-dose RT (p = 0.05) were variables predictive of improved PFS on univariate analysis. In multivariate analysis, only postoperative high-dose RT was independent predictors of PFS (p = 0.04). CONCLUSIONS: The observed pattern of failure was mainly local, but one fifth of the patients presented with a concomitant spinal or brain component. Postoperative high-dose RT appears to significantly reduce the rate of tumor progression.
Keywords
Adolescent, Adult, Aged, Analysis of Variance, Brain Neoplasms/secondary, Child, Combined Modality Therapy/methods, Disease Progression, Disease-Free Survival, Ependymoma/mortality, Ependymoma/radiotherapy, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy/adverse effects, Radiotherapy Dosage, Retrospective Studies, Spinal Neoplasms/mortality, Spinal Neoplasms/radiotherapy, Treatment Failure, Young Adult
Pubmed
Web of science
Create date
02/09/2009 14:02
Last modification date
20/08/2019 14:14
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