CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis.
Details
Serval ID
serval:BIB_5B9811DBA8DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis.
Journal
Clinical Immunology
ISSN
1521-6616[print], 1521-6616[linking]
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
123
Number
1
Pages
105-113
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
CD8+ T cells may play an important role in multiple sclerosis (MS). Whether these cells would be involved in early stages of MS is unclear. We enrolled 52 patients with suspected MS, determined the recruitment of their highly differentiated (CCR7-/CD45RA+ or -) T cells (T(HD)) in the CSF as compared to peripheral blood and followed them for 12+/-7.3 months. A ROC curve showed that a CD8+/CD4+ T(HD) cells ratio of 0.94 helped to distinguish relapsing-remitting (RR-MS) and possible MS (Po-MS) from primary-progressive MS (PP-MS) and other neurological diseases patients (OND) patients (p=0.039), risk ratio of 2.29 (95% CI: 1.13-4.66; p=0.006). The CSF enrichment in CD8+ T(HD) cells was greater than in CD4+ T(HD) cells in RR/Po-MS patients (p=0.024) and than in CD8+ T(HD) cells in PP-MS/OND patients (p=0.006). These data suggest that CD8+ T(HD) cells play a role in the early stages of RR-MS.
Keywords
CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cohort Studies, Humans, Multiple Sclerosis, Chronic Progressive/blood, Multiple Sclerosis, Chronic Progressive/cerebrospinal fluid, Multiple Sclerosis, Relapsing-Remitting/blood, Multiple Sclerosis, Relapsing-Remitting/cerebrospinal fluid, ROC Curve
Pubmed
Web of science
Create date
25/01/2008 15:56
Last modification date
20/08/2019 15:14
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