Evolutionary patterns of MHC class II B in owls and their implications for the understanding of avian MHC evolution.

Details

Serval ID
serval:BIB_5B95D7E0D7F1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evolutionary patterns of MHC class II B in owls and their implications for the understanding of avian MHC evolution.
Journal
Molecular Biology and Evolution
Author(s)
Burri R., Niculita Hirzel Hélène, Salamin N., Roulin A., Fumagalli L.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Publication state
Published
Issued date
06/2008
Peer-reviewed
Oui
Volume
25
Number
6
Pages
1180-1191
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Owing to its special mode of evolution and central role in the adaptive immune system, the major histocompatibility complex (MHC) has become the focus of diverse disciplines such as immunology, evolutionary ecology, and molecular evolution. MHC evolution has been studied extensively in diverse vertebrate lineages over the last few decades, and it has been suggested that birds differ from the established mammalian norm. Mammalian MHC genes evolve independently, and duplication history (i.e., orthology) can usually be traced back within lineages. In birds, this has been observed in only 3 pairs of closely related species. Here we report strong evidence for the persistence of orthology of MHC genes throughout an entire avian order. Phylogenetic reconstructions of MHC class II B genes in 14 species of owls trace back orthology over tens of thousands of years in exon 3. Moreover, exon 2 sequences from several species show closer relationships than sequences within species, resembling transspecies evolution typically observed in mammals. Thus, although previous studies suggested that long-term evolutionary dynamics of the avian MHC was characterized by high rates of concerted evolution, resulting in rapid masking of orthology, our results question the generality of this conclusion. The owl MHC thus opens new perspectives for a more comprehensive understanding of avian MHC evolution.

Keywords
Animals, Avian Proteins/classification, Avian Proteins/genetics, Base Sequence, Evolution, Molecular, Exons, Histocompatibility Antigens Class II/classification, Histocompatibility Antigens Class II/genetics, Molecular Sequence Data, Phylogeny, Recombination, Genetic, Sequence Alignment, Sequence Analysis, DNA, Strigiformes/genetics, Strigiformes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
15/03/2008 14:08
Last modification date
20/08/2019 15:14
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