Redox dysregulation, neurodevelopment, and schizophrenia.
Details
Serval ID
serval:BIB_5B7B7882D993
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Redox dysregulation, neurodevelopment, and schizophrenia.
Journal
Current opinion in neurobiology
ISSN
1873-6882[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
19
Number
2
Pages
220-30
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
In schizophrenia, a developmental redox dysregulation constitutes one 'hub' on which converge genetic impairments of glutathione synthesis and environmental vulnerability factors generating oxidative stress. Their timing at critical periods of neurodevelopment could play a decisive role in inducing impairment of neural connectivity and synchronization as observed in schizophrenia. In experimental models, such redox dysregulation induces anomalies strikingly similar to those observed in patients. This is mediated by hypoactive NMDA receptors, impairment of fast-spiking parvalbumin GABA interneurons and deficit in myelination. A treatment restoring the redox balance without side effects yields improvements of negative symptoms in chronic patients. Novel interventions based on these mechanisms if applied in early phases of the disease hold great therapeutic promise.
Pubmed
Web of science
Create date
17/08/2009 14:22
Last modification date
20/08/2019 15:14